Familial Mediterranean Fever without Fever
Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease commonly observed around the Mediterranean basin presenting as recurrent febrile episodes. We herein describe a Japanese case of genetically-confirmed FMF, in which fever was lacking during attacks. An otherwise healthy...
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| Veröffentlicht in: | Internal Medicine 2020/05/15, Vol.59(10), pp.1267-1270 |
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| container_title | Internal Medicine |
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| creator | Hotta, Yuma Kawasaki, Tatsuya Kotani, Tomoya Okada, Hiroshi Ikeda, Kanami Yamane, Satoki Yamada, Nobuhisa Sekoguchi, Satoru Isozaki, Yutaka Nagao, Yasuyuki Murotani, Masahiro Oyamada, Hirokazu |
| description | Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease commonly observed around the Mediterranean basin presenting as recurrent febrile episodes. We herein describe a Japanese case of genetically-confirmed FMF, in which fever was lacking during attacks. An otherwise healthy 34-year-old man presented with frequent episodes of abdominal pain, which resolved spontaneously. During the attacks, the patient was afebrile, but the inflammatory marker levels in his blood were increased. Abdominal CT demonstrated enhancement of the jejunal membrane. After the initiation of colchicine therapy, the patient experienced no attacks for more than one year. The diagnosis of FMF was confirmed by a genetic analysis. |
| doi_str_mv | 10.2169/internalmedicine.3175-19 |
| format | Article |
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We herein describe a Japanese case of genetically-confirmed FMF, in which fever was lacking during attacks. An otherwise healthy 34-year-old man presented with frequent episodes of abdominal pain, which resolved spontaneously. During the attacks, the patient was afebrile, but the inflammatory marker levels in his blood were increased. Abdominal CT demonstrated enhancement of the jejunal membrane. After the initiation of colchicine therapy, the patient experienced no attacks for more than one year. The diagnosis of FMF was confirmed by a genetic analysis.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.3175-19</identifier><identifier>PMID: 32051376</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>afebrile ; Case Report ; Colchicine ; diagnosis ; Familial Mediterranean fever ; Fever ; Genetic analysis ; Hereditary diseases ; Inflammation ; Internal medicine ; mutation</subject><ispartof>Internal Medicine, 2020/05/15, Vol.59(10), pp.1267-1270</ispartof><rights>2020 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2020</rights><rights>Copyright © 2020 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c597t-9826bd56cf76925411b849e4b0cd14042f138b4dc4664e192e3f27195c57b77a3</citedby><cites>FETCH-LOGICAL-c597t-9826bd56cf76925411b849e4b0cd14042f138b4dc4664e192e3f27195c57b77a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303446/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303446/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1881,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32051376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hotta, Yuma</creatorcontrib><creatorcontrib>Kawasaki, Tatsuya</creatorcontrib><creatorcontrib>Kotani, Tomoya</creatorcontrib><creatorcontrib>Okada, Hiroshi</creatorcontrib><creatorcontrib>Ikeda, Kanami</creatorcontrib><creatorcontrib>Yamane, Satoki</creatorcontrib><creatorcontrib>Yamada, Nobuhisa</creatorcontrib><creatorcontrib>Sekoguchi, Satoru</creatorcontrib><creatorcontrib>Isozaki, Yutaka</creatorcontrib><creatorcontrib>Nagao, Yasuyuki</creatorcontrib><creatorcontrib>Murotani, Masahiro</creatorcontrib><creatorcontrib>Oyamada, Hirokazu</creatorcontrib><title>Familial Mediterranean Fever without Fever</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease commonly observed around the Mediterranean basin presenting as recurrent febrile episodes. We herein describe a Japanese case of genetically-confirmed FMF, in which fever was lacking during attacks. An otherwise healthy 34-year-old man presented with frequent episodes of abdominal pain, which resolved spontaneously. During the attacks, the patient was afebrile, but the inflammatory marker levels in his blood were increased. Abdominal CT demonstrated enhancement of the jejunal membrane. After the initiation of colchicine therapy, the patient experienced no attacks for more than one year. The diagnosis of FMF was confirmed by a genetic analysis.</description><subject>afebrile</subject><subject>Case Report</subject><subject>Colchicine</subject><subject>diagnosis</subject><subject>Familial Mediterranean fever</subject><subject>Fever</subject><subject>Genetic analysis</subject><subject>Hereditary diseases</subject><subject>Inflammation</subject><subject>Internal medicine</subject><subject>mutation</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNplkVtLAzEQhYMotl7-ghR8EWFr7tm8CCJWBcUXfQ7ZdNambHdrslvx35ultWh9mRDyzZmcOQiNCB5TIvWVr1sIta0WMPXO1zBmRImM6D00JIzrTFEm9tEQa5JnNJUBOopxjjHLlaaHaMAoFoQpOUSXE7vwlbfV6DlpJdVga7D1aAIrCKNP386arl3fTtBBaasIp5vzGL1N7l5vH7Knl_vH25unzAmt2kznVBZTIV2ppKaCE1LkXAMvsJsSjjktCcsLPnVcSg5EU2AlVUQLJ1ShlGXH6Hqtu-yKZNBB3QZbmWXwCxu-TGO9-ftS-5l5b1ZGMcw4l0ngYiMQmo8OYmsWPjqoqmSt6aJJy-GKKZGzhJ7voPOm6zebKI5zIZMbnah8TbnQxBig3H6GYNMHYnYDMX0ghvStZ7_NbBt_EkjAyxqYx9a-wxawofWugv_KQvdTU92M2JJuZoOBmn0DqQmoVw</recordid><startdate>20200515</startdate><enddate>20200515</enddate><creator>Hotta, Yuma</creator><creator>Kawasaki, Tatsuya</creator><creator>Kotani, Tomoya</creator><creator>Okada, Hiroshi</creator><creator>Ikeda, Kanami</creator><creator>Yamane, Satoki</creator><creator>Yamada, Nobuhisa</creator><creator>Sekoguchi, Satoru</creator><creator>Isozaki, Yutaka</creator><creator>Nagao, Yasuyuki</creator><creator>Murotani, Masahiro</creator><creator>Oyamada, Hirokazu</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200515</creationdate><title>Familial Mediterranean Fever without Fever</title><author>Hotta, Yuma ; Kawasaki, Tatsuya ; Kotani, Tomoya ; Okada, Hiroshi ; Ikeda, Kanami ; Yamane, Satoki ; Yamada, Nobuhisa ; Sekoguchi, Satoru ; Isozaki, Yutaka ; Nagao, Yasuyuki ; Murotani, Masahiro ; Oyamada, Hirokazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c597t-9826bd56cf76925411b849e4b0cd14042f138b4dc4664e192e3f27195c57b77a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>afebrile</topic><topic>Case Report</topic><topic>Colchicine</topic><topic>diagnosis</topic><topic>Familial Mediterranean fever</topic><topic>Fever</topic><topic>Genetic analysis</topic><topic>Hereditary diseases</topic><topic>Inflammation</topic><topic>Internal medicine</topic><topic>mutation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hotta, Yuma</creatorcontrib><creatorcontrib>Kawasaki, Tatsuya</creatorcontrib><creatorcontrib>Kotani, Tomoya</creatorcontrib><creatorcontrib>Okada, Hiroshi</creatorcontrib><creatorcontrib>Ikeda, Kanami</creatorcontrib><creatorcontrib>Yamane, Satoki</creatorcontrib><creatorcontrib>Yamada, Nobuhisa</creatorcontrib><creatorcontrib>Sekoguchi, Satoru</creatorcontrib><creatorcontrib>Isozaki, Yutaka</creatorcontrib><creatorcontrib>Nagao, Yasuyuki</creatorcontrib><creatorcontrib>Murotani, Masahiro</creatorcontrib><creatorcontrib>Oyamada, Hirokazu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hotta, Yuma</au><au>Kawasaki, Tatsuya</au><au>Kotani, Tomoya</au><au>Okada, Hiroshi</au><au>Ikeda, Kanami</au><au>Yamane, Satoki</au><au>Yamada, Nobuhisa</au><au>Sekoguchi, Satoru</au><au>Isozaki, Yutaka</au><au>Nagao, Yasuyuki</au><au>Murotani, Masahiro</au><au>Oyamada, Hirokazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Familial Mediterranean Fever without Fever</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2020-05-15</date><risdate>2020</risdate><volume>59</volume><issue>10</issue><spage>1267</spage><epage>1270</epage><pages>1267-1270</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease commonly observed around the Mediterranean basin presenting as recurrent febrile episodes. We herein describe a Japanese case of genetically-confirmed FMF, in which fever was lacking during attacks. An otherwise healthy 34-year-old man presented with frequent episodes of abdominal pain, which resolved spontaneously. During the attacks, the patient was afebrile, but the inflammatory marker levels in his blood were increased. Abdominal CT demonstrated enhancement of the jejunal membrane. After the initiation of colchicine therapy, the patient experienced no attacks for more than one year. The diagnosis of FMF was confirmed by a genetic analysis.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>32051376</pmid><doi>10.2169/internalmedicine.3175-19</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | afebrile Case Report Colchicine diagnosis Familial Mediterranean fever Fever Genetic analysis Hereditary diseases Inflammation Internal medicine mutation |
| title | Familial Mediterranean Fever without Fever |
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