Age-associated changes in 4D flow CMR derived Tricuspid Valvular Flow and Right Ventricular Blood Flow Kinetic Energy
Assessment of right ventricular (RV) diastolic function is not routinely carried out. This is due to standard two-dimensional imaging techniques being unreliable. Four-dimensional flow (4D flow) derived right ventricular blood flow kinetic energy assessment could circumvent the issues of the current...
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| Veröffentlicht in: | Scientific reports 2020-06, Vol.10 (1), p.9908-9908, Article 9908 |
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| creator | Barker, Natasha Zafar, Hamza Fidock, Benjamin Elhawaz, Alaa Al-Mohammad, Abdallah Rothman, Alexander Kiely, David G. van der Geest, R. J. Westenberg, Jos Swift, Andrew J. Wild, James M. Plein, Sven Garg, Pankaj |
| description | Assessment of right ventricular (RV) diastolic function is not routinely carried out. This is due to standard two-dimensional imaging techniques being unreliable. Four-dimensional flow (4D flow) derived right ventricular blood flow kinetic energy assessment could circumvent the issues of the current imaging modalities. It also remains unknown whether there is an association between right ventricular blood flow kinetic energy (KE) and healthy ageing. We hypothesise that healthy ageing requires maintaining normal RV intra-cavity blood flow as quantified using KE method. The main objective of this study was to investigate the effect of healthy ageing on tricuspid through-plane flow and right ventricular blood flow kinetic energy. In this study, fifty-three healthy participants received a 4D flow cardiovascular magnetic resonance (CMR) scan on 1.5 T Philips Ingenia. Cine segmentation and 4D flow analysis were performed using dedicated software. Standard statistical methods were carried out to investigate the associations. Both RV E-wave KEi
EDV
(r = −0.3, P = 0.04) and A-wave KEi
EDV
(r = 0.42, P |
| doi_str_mv | 10.1038/s41598-020-66958-y |
| format | Article |
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EDV
(r = −0.3, P = 0.04) and A-wave KEi
EDV
(r = 0.42, P < 0.01) showed an association with healthy ageing. Additionally, the right ventricular blood flow KEi
EDV
E/A ratio demonstrated the strongest association with healthy ageing (r = −0.53, P < 0.01) when compared to all RV functional and haemodynamic parameters. Furthermore, in a multivariate regression model, KEi
EDV
E/A ratio and 4D flow derived tricuspid valve stroke volume demonstrated independent association to healthy ageing (beta −0.02 and 0.68 respectively, P < 0.01). Ageing is independently associated with 4D flow derived tricuspid stroke volume and RV blood flow KE E/A ratio. These novel 4D flow CMR derived imaging markers have future potential for RV diastolic assessment.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-66958-y</identifier><identifier>PMID: 32555252</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308 ; 692/4019 ; Adult ; Aged ; Aged, 80 and over ; Aging ; Blood flow ; Blood Flow Velocity ; Energy audits ; Female ; Follow-Up Studies ; Heart ; Hemodynamics ; Humanities and Social Sciences ; Humans ; Image Interpretation, Computer-Assisted - methods ; Kinetic energy ; Magnetic Resonance Imaging, Cine - methods ; Male ; Middle Aged ; multidisciplinary ; Observer Variation ; Plane flow ; Prospective Studies ; Science ; Science (multidisciplinary) ; Segmentation ; Statistical methods ; Stroke ; Stroke Volume ; Tricuspid valve ; Tricuspid Valve - physiology ; Ventricle ; Ventricular Dysfunction, Right - physiopathology ; Ventricular Function, Right - physiology ; Young Adult</subject><ispartof>Scientific reports, 2020-06, Vol.10 (1), p.9908-9908, Article 9908</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-cd59cc744fab37f3c32f5b3412ffe47e47a7bfb97df8c6b55b62b5addde4d2a73</citedby><cites>FETCH-LOGICAL-c474t-cd59cc744fab37f3c32f5b3412ffe47e47a7bfb97df8c6b55b62b5addde4d2a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303161/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303161/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32555252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barker, Natasha</creatorcontrib><creatorcontrib>Zafar, Hamza</creatorcontrib><creatorcontrib>Fidock, Benjamin</creatorcontrib><creatorcontrib>Elhawaz, Alaa</creatorcontrib><creatorcontrib>Al-Mohammad, Abdallah</creatorcontrib><creatorcontrib>Rothman, Alexander</creatorcontrib><creatorcontrib>Kiely, David G.</creatorcontrib><creatorcontrib>van der Geest, R. J.</creatorcontrib><creatorcontrib>Westenberg, Jos</creatorcontrib><creatorcontrib>Swift, Andrew J.</creatorcontrib><creatorcontrib>Wild, James M.</creatorcontrib><creatorcontrib>Plein, Sven</creatorcontrib><creatorcontrib>Garg, Pankaj</creatorcontrib><title>Age-associated changes in 4D flow CMR derived Tricuspid Valvular Flow and Right Ventricular Blood Flow Kinetic Energy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Assessment of right ventricular (RV) diastolic function is not routinely carried out. This is due to standard two-dimensional imaging techniques being unreliable. Four-dimensional flow (4D flow) derived right ventricular blood flow kinetic energy assessment could circumvent the issues of the current imaging modalities. It also remains unknown whether there is an association between right ventricular blood flow kinetic energy (KE) and healthy ageing. We hypothesise that healthy ageing requires maintaining normal RV intra-cavity blood flow as quantified using KE method. The main objective of this study was to investigate the effect of healthy ageing on tricuspid through-plane flow and right ventricular blood flow kinetic energy. In this study, fifty-three healthy participants received a 4D flow cardiovascular magnetic resonance (CMR) scan on 1.5 T Philips Ingenia. Cine segmentation and 4D flow analysis were performed using dedicated software. Standard statistical methods were carried out to investigate the associations. Both RV E-wave KEi
EDV
(r = −0.3, P = 0.04) and A-wave KEi
EDV
(r = 0.42, P < 0.01) showed an association with healthy ageing. Additionally, the right ventricular blood flow KEi
EDV
E/A ratio demonstrated the strongest association with healthy ageing (r = −0.53, P < 0.01) when compared to all RV functional and haemodynamic parameters. Furthermore, in a multivariate regression model, KEi
EDV
E/A ratio and 4D flow derived tricuspid valve stroke volume demonstrated independent association to healthy ageing (beta −0.02 and 0.68 respectively, P < 0.01). Ageing is independently associated with 4D flow derived tricuspid stroke volume and RV blood flow KE E/A ratio. These novel 4D flow CMR derived imaging markers have future potential for RV diastolic assessment.</description><subject>692/308</subject><subject>692/4019</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Blood flow</subject><subject>Blood Flow Velocity</subject><subject>Energy audits</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Hemodynamics</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Kinetic energy</subject><subject>Magnetic Resonance Imaging, Cine - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Observer Variation</subject><subject>Plane flow</subject><subject>Prospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Segmentation</subject><subject>Statistical methods</subject><subject>Stroke</subject><subject>Stroke Volume</subject><subject>Tricuspid valve</subject><subject>Tricuspid Valve - physiology</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Right - physiopathology</subject><subject>Ventricular Function, Right - physiology</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rFTEUhoNYbKn9Ay4k4MbNaD4nMxuhXlsVW4RSuw2ZfMxNmZtck5kr99-bcWptXTQEEnif855zeAF4hdE7jGjzPjPM26ZCBFV13fKm2j8DRwQxXhFKyPMH_0NwkvMtKoeTluH2BTikhHNOODkC02lvK5Vz1F6N1kC9VqG3GfoA2SfohvgLri6voLHJ74p8nbye8tYbeKOG3TSoBM9nRgUDr3y_HuGNDeMMzdLHIUazAN98sKPX8CzY1O9fggOnhmxP7t5j8OP87Hr1pbr4_vnr6vSi0kywsdKGt1oLxpzqqHBUU-J4RxkmzlkmylWic10rjGt03XHe1aTjyhhjmSFK0GPwYfHdTt3GGj3Ppga5TX6j0l5G5eVjJfi17ONOCooornExeHtnkOLPyeZRbnzWdhhUsHHKkpQUKMIc0YK--Q-9jVMKZb2ZYlw0hPFCkYXSKeacrLsfBiM5ByuXYGUJVv4JVu5L0euHa9yX_I2xAHQBcpFKfulf7ydsfwParrDD</recordid><startdate>20200618</startdate><enddate>20200618</enddate><creator>Barker, Natasha</creator><creator>Zafar, Hamza</creator><creator>Fidock, Benjamin</creator><creator>Elhawaz, Alaa</creator><creator>Al-Mohammad, Abdallah</creator><creator>Rothman, Alexander</creator><creator>Kiely, David G.</creator><creator>van der Geest, R. J.</creator><creator>Westenberg, Jos</creator><creator>Swift, Andrew J.</creator><creator>Wild, James M.</creator><creator>Plein, Sven</creator><creator>Garg, Pankaj</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200618</creationdate><title>Age-associated changes in 4D flow CMR derived Tricuspid Valvular Flow and Right Ventricular Blood Flow Kinetic Energy</title><author>Barker, Natasha ; Zafar, Hamza ; Fidock, Benjamin ; Elhawaz, Alaa ; Al-Mohammad, Abdallah ; Rothman, Alexander ; Kiely, David G. ; van der Geest, R. 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J.</creatorcontrib><creatorcontrib>Westenberg, Jos</creatorcontrib><creatorcontrib>Swift, Andrew J.</creatorcontrib><creatorcontrib>Wild, James M.</creatorcontrib><creatorcontrib>Plein, Sven</creatorcontrib><creatorcontrib>Garg, Pankaj</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barker, Natasha</au><au>Zafar, Hamza</au><au>Fidock, Benjamin</au><au>Elhawaz, Alaa</au><au>Al-Mohammad, Abdallah</au><au>Rothman, Alexander</au><au>Kiely, David G.</au><au>van der Geest, R. J.</au><au>Westenberg, Jos</au><au>Swift, Andrew J.</au><au>Wild, James M.</au><au>Plein, Sven</au><au>Garg, Pankaj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-associated changes in 4D flow CMR derived Tricuspid Valvular Flow and Right Ventricular Blood Flow Kinetic Energy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-06-18</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>9908</spage><epage>9908</epage><pages>9908-9908</pages><artnum>9908</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Assessment of right ventricular (RV) diastolic function is not routinely carried out. This is due to standard two-dimensional imaging techniques being unreliable. Four-dimensional flow (4D flow) derived right ventricular blood flow kinetic energy assessment could circumvent the issues of the current imaging modalities. It also remains unknown whether there is an association between right ventricular blood flow kinetic energy (KE) and healthy ageing. We hypothesise that healthy ageing requires maintaining normal RV intra-cavity blood flow as quantified using KE method. The main objective of this study was to investigate the effect of healthy ageing on tricuspid through-plane flow and right ventricular blood flow kinetic energy. In this study, fifty-three healthy participants received a 4D flow cardiovascular magnetic resonance (CMR) scan on 1.5 T Philips Ingenia. Cine segmentation and 4D flow analysis were performed using dedicated software. Standard statistical methods were carried out to investigate the associations. Both RV E-wave KEi
EDV
(r = −0.3, P = 0.04) and A-wave KEi
EDV
(r = 0.42, P < 0.01) showed an association with healthy ageing. Additionally, the right ventricular blood flow KEi
EDV
E/A ratio demonstrated the strongest association with healthy ageing (r = −0.53, P < 0.01) when compared to all RV functional and haemodynamic parameters. Furthermore, in a multivariate regression model, KEi
EDV
E/A ratio and 4D flow derived tricuspid valve stroke volume demonstrated independent association to healthy ageing (beta −0.02 and 0.68 respectively, P < 0.01). Ageing is independently associated with 4D flow derived tricuspid stroke volume and RV blood flow KE E/A ratio. These novel 4D flow CMR derived imaging markers have future potential for RV diastolic assessment.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32555252</pmid><doi>10.1038/s41598-020-66958-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Nature Free; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 692/308 692/4019 Adult Aged Aged, 80 and over Aging Blood flow Blood Flow Velocity Energy audits Female Follow-Up Studies Heart Hemodynamics Humanities and Social Sciences Humans Image Interpretation, Computer-Assisted - methods Kinetic energy Magnetic Resonance Imaging, Cine - methods Male Middle Aged multidisciplinary Observer Variation Plane flow Prospective Studies Science Science (multidisciplinary) Segmentation Statistical methods Stroke Stroke Volume Tricuspid valve Tricuspid Valve - physiology Ventricle Ventricular Dysfunction, Right - physiopathology Ventricular Function, Right - physiology Young Adult |
| title | Age-associated changes in 4D flow CMR derived Tricuspid Valvular Flow and Right Ventricular Blood Flow Kinetic Energy |
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