The Missing Electrostatic Interactions Between DNA Substrate and Sulfolobus solfataricus DNA Photolyase: What is the Role of Charged Amino Acids in Thermophilic DNA Binding Proteins?

DNA photolyase can be used to study how a protein with its required cofactor has adapted over a large temperature range. The enzymatic activity and thermodynamics of substrate binding for protein from Sulfolobus solfataricus were directly compared to protein from Escherichia coli. Turnover numbers a...

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Veröffentlicht in:	The journal of physical chemistry. B 2016-10, Vol.120 (39), p.10234-10242
Hauptverfasser:	Gindt, Yvonne M, Edani, Ban H, Olejnikova, Antonia, Roberts, Ariana N, Munshi, Sudipto, Stanley, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Amino Acids - metabolism Calorimetry Deoxyribodipyrimidine Photo-Lyase - chemistry Deoxyribodipyrimidine Photo-Lyase - isolation & purification Deoxyribodipyrimidine Photo-Lyase - metabolism DNA - chemistry DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Static Electricity Sulfolobus solfataricus - enzymology Temperature
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