The association of lung ultrasound images with COVID‐19 infection in an emergency room cohort
Summary Lung ultrasound could facilitate the triage of patients with suspected COVID‐19 infection admitted to the emergency room. We developed a predictive model for COVID‐19 diagnosis based on lung ultrasound and clinical features. We used ultrasound to image the lung bilaterally at two anterior si...
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Veröffentlicht in: | Anaesthesia 2020-12, Vol.75 (12), p.1620-1625 |
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creator | Bar, S. Lecourtois, A. Diouf, M. Goldberg, E. Bourbon, C. Arnaud, E. Domisse, L. Dupont, H. Gosset, P. |
description | Summary
Lung ultrasound could facilitate the triage of patients with suspected COVID‐19 infection admitted to the emergency room. We developed a predictive model for COVID‐19 diagnosis based on lung ultrasound and clinical features. We used ultrasound to image the lung bilaterally at two anterior sites, one and two hands below each clavicle, and a posterolateral site that was the posterior transverse continuation from the lower anterior site. We studied 100 patients, 31 of whom had a COVID‐19 positive reverse transcriptase polymerase chain reaction. A positive test was independently associated with: quick sequential organ failure assessment score ≥1; ≥3 B‐lines at the upper site; consolidation and thickened pleura at the lower site; and thickened pleura line at the posterolateral site. The model discrimination was an area (95%CI) under the receiver operating characteristic curve of 0.82 (0.75–0.90). The characteristics (95%CI) of the model’s diagnostic threshold, applied to the population from which it was derived, were: sensitivity, 97% (83–100%); specificity, 62% (50–74%); positive predictive value, 54% (41–98%); and negative predictive value, 98% (88–99%). This model may facilitate triage of patients with suspected COVID‐19 infection admitted to the emergency room. |
doi_str_mv | 10.1111/anae.15175 |
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Lung ultrasound could facilitate the triage of patients with suspected COVID‐19 infection admitted to the emergency room. We developed a predictive model for COVID‐19 diagnosis based on lung ultrasound and clinical features. We used ultrasound to image the lung bilaterally at two anterior sites, one and two hands below each clavicle, and a posterolateral site that was the posterior transverse continuation from the lower anterior site. We studied 100 patients, 31 of whom had a COVID‐19 positive reverse transcriptase polymerase chain reaction. A positive test was independently associated with: quick sequential organ failure assessment score ≥1; ≥3 B‐lines at the upper site; consolidation and thickened pleura at the lower site; and thickened pleura line at the posterolateral site. The model discrimination was an area (95%CI) under the receiver operating characteristic curve of 0.82 (0.75–0.90). The characteristics (95%CI) of the model’s diagnostic threshold, applied to the population from which it was derived, were: sensitivity, 97% (83–100%); specificity, 62% (50–74%); positive predictive value, 54% (41–98%); and negative predictive value, 98% (88–99%). This model may facilitate triage of patients with suspected COVID‐19 infection admitted to the emergency room.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/anae.15175</identifier><identifier>PMID: 32520406</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Area Under Curve ; Clavicle ; Cohort Studies ; Coronavirus Infections - diagnosis ; Coronavirus Infections - diagnostic imaging ; COVID-19 ; Diagnostic systems ; Emergencies ; Emergency medical care ; Emergency Medical Services ; Emergency Service, Hospital - organization & administration ; Emergency Service, Hospital - statistics & numerical data ; Female ; Humans ; Infections ; Life Sciences ; Lung - diagnostic imaging ; lung ultrasound ; Lungs ; Male ; Medical imaging ; Middle Aged ; Organ Dysfunction Scores ; Original ; Pandemics ; Pleura ; Pleura - diagnostic imaging ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - diagnostic imaging ; Polymerase Chain Reaction ; Prediction models ; Predictive Value of Tests ; RNA-directed DNA polymerase ; ROC Curve ; Sensitivity and Specificity ; Triage ; Ultrasonic imaging ; Ultrasonography ; Ultrasound</subject><ispartof>Anaesthesia, 2020-12, Vol.75 (12), p.1620-1625</ispartof><rights>2020 Association of Anaesthetists</rights><rights>2020 Association of Anaesthetists.</rights><rights>Copyright © 2020 Association of Anaesthetists</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5105-c109acc4030fd5180e0f4ca8b9a72d76dc17070446cc525c3803fe303274b9aa3</citedby><cites>FETCH-LOGICAL-c5105-c109acc4030fd5180e0f4ca8b9a72d76dc17070446cc525c3803fe303274b9aa3</cites><orcidid>0000-0002-5644-3412 ; 0000-0002-4630-5833 ; 0000-0001-9528-2669</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fanae.15175$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fanae.15175$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32520406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://u-picardie.hal.science/hal-03576421$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bar, S.</creatorcontrib><creatorcontrib>Lecourtois, A.</creatorcontrib><creatorcontrib>Diouf, M.</creatorcontrib><creatorcontrib>Goldberg, E.</creatorcontrib><creatorcontrib>Bourbon, C.</creatorcontrib><creatorcontrib>Arnaud, E.</creatorcontrib><creatorcontrib>Domisse, L.</creatorcontrib><creatorcontrib>Dupont, H.</creatorcontrib><creatorcontrib>Gosset, P.</creatorcontrib><title>The association of lung ultrasound images with COVID‐19 infection in an emergency room cohort</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
Lung ultrasound could facilitate the triage of patients with suspected COVID‐19 infection admitted to the emergency room. We developed a predictive model for COVID‐19 diagnosis based on lung ultrasound and clinical features. We used ultrasound to image the lung bilaterally at two anterior sites, one and two hands below each clavicle, and a posterolateral site that was the posterior transverse continuation from the lower anterior site. We studied 100 patients, 31 of whom had a COVID‐19 positive reverse transcriptase polymerase chain reaction. A positive test was independently associated with: quick sequential organ failure assessment score ≥1; ≥3 B‐lines at the upper site; consolidation and thickened pleura at the lower site; and thickened pleura line at the posterolateral site. The model discrimination was an area (95%CI) under the receiver operating characteristic curve of 0.82 (0.75–0.90). The characteristics (95%CI) of the model’s diagnostic threshold, applied to the population from which it was derived, were: sensitivity, 97% (83–100%); specificity, 62% (50–74%); positive predictive value, 54% (41–98%); and negative predictive value, 98% (88–99%). This model may facilitate triage of patients with suspected COVID‐19 infection admitted to the emergency room.</description><subject>Adult</subject><subject>Aged</subject><subject>Area Under Curve</subject><subject>Clavicle</subject><subject>Cohort Studies</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - diagnostic imaging</subject><subject>COVID-19</subject><subject>Diagnostic systems</subject><subject>Emergencies</subject><subject>Emergency medical care</subject><subject>Emergency Medical Services</subject><subject>Emergency Service, Hospital - organization & administration</subject><subject>Emergency Service, Hospital - statistics & numerical data</subject><subject>Female</subject><subject>Humans</subject><subject>Infections</subject><subject>Life Sciences</subject><subject>Lung - diagnostic imaging</subject><subject>lung ultrasound</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Organ Dysfunction Scores</subject><subject>Original</subject><subject>Pandemics</subject><subject>Pleura</subject><subject>Pleura - diagnostic imaging</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - diagnostic imaging</subject><subject>Polymerase Chain Reaction</subject><subject>Prediction models</subject><subject>Predictive Value of Tests</subject><subject>RNA-directed DNA polymerase</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Triage</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Ultrasound</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9O3DAQhy1EBdulFx4AWeJEpcD4X5K9IK0WWpBW5QK9WsZxNkZZG-xk0d54BJ6xT1IvoahwYC6W7G8-z-iH0D6BY5LqRDlljokghdhCI8JykVHgfBuNAIBllMNkF32N8Q6A0JKUO2iXUZEQyEdIXjcGqxi9tqqz3mFf47Z3C9y3XVDR967CdqkWJuJH2zV4dvX78uzP0zOZYOtqo196rMPKYbM0YWGcXuPg_RJr3_jQ7aEvtWqj-fZ6jtHNj_Pr2UU2v_p5OZvOMy0IiEwTmCitOTCoK0FKMFBzrcrbiSpoVeSVJgUUaatca0GFZiWw2jBgtOCJUWyMTgfvfX-7NJU2Lo3fyvuQhg9r6ZWV71-cbeTCr2TBAHgOSXA0CJoPbRfTudzcARNFzilZkcQevn4W_ENvYifvfB9c2k9SLkoBbFNj9H2gdPAxBlO_aQnITXByE5x8CS7BB__P_4b-SyoBZAAebWvWn6jk9Nf0fJD-BaWKoyk</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Bar, S.</creator><creator>Lecourtois, A.</creator><creator>Diouf, M.</creator><creator>Goldberg, E.</creator><creator>Bourbon, C.</creator><creator>Arnaud, E.</creator><creator>Domisse, L.</creator><creator>Dupont, H.</creator><creator>Gosset, P.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5644-3412</orcidid><orcidid>https://orcid.org/0000-0002-4630-5833</orcidid><orcidid>https://orcid.org/0000-0001-9528-2669</orcidid></search><sort><creationdate>202012</creationdate><title>The association of lung ultrasound images with COVID‐19 infection in an emergency room cohort</title><author>Bar, S. ; Lecourtois, A. ; Diouf, M. ; Goldberg, E. ; Bourbon, C. ; Arnaud, E. ; Domisse, L. ; Dupont, H. ; Gosset, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5105-c109acc4030fd5180e0f4ca8b9a72d76dc17070446cc525c3803fe303274b9aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Area Under Curve</topic><topic>Clavicle</topic><topic>Cohort Studies</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - diagnostic imaging</topic><topic>COVID-19</topic><topic>Diagnostic systems</topic><topic>Emergencies</topic><topic>Emergency medical care</topic><topic>Emergency Medical Services</topic><topic>Emergency Service, Hospital - organization & administration</topic><topic>Emergency Service, Hospital - statistics & numerical data</topic><topic>Female</topic><topic>Humans</topic><topic>Infections</topic><topic>Life Sciences</topic><topic>Lung - diagnostic imaging</topic><topic>lung ultrasound</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Organ Dysfunction Scores</topic><topic>Original</topic><topic>Pandemics</topic><topic>Pleura</topic><topic>Pleura - diagnostic imaging</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - diagnostic imaging</topic><topic>Polymerase Chain Reaction</topic><topic>Prediction models</topic><topic>Predictive Value of Tests</topic><topic>RNA-directed DNA polymerase</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Triage</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bar, S.</creatorcontrib><creatorcontrib>Lecourtois, A.</creatorcontrib><creatorcontrib>Diouf, M.</creatorcontrib><creatorcontrib>Goldberg, E.</creatorcontrib><creatorcontrib>Bourbon, C.</creatorcontrib><creatorcontrib>Arnaud, E.</creatorcontrib><creatorcontrib>Domisse, L.</creatorcontrib><creatorcontrib>Dupont, H.</creatorcontrib><creatorcontrib>Gosset, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bar, S.</au><au>Lecourtois, A.</au><au>Diouf, M.</au><au>Goldberg, E.</au><au>Bourbon, C.</au><au>Arnaud, E.</au><au>Domisse, L.</au><au>Dupont, H.</au><au>Gosset, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of lung ultrasound images with COVID‐19 infection in an emergency room cohort</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2020-12</date><risdate>2020</risdate><volume>75</volume><issue>12</issue><spage>1620</spage><epage>1625</epage><pages>1620-1625</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><abstract>Summary
Lung ultrasound could facilitate the triage of patients with suspected COVID‐19 infection admitted to the emergency room. We developed a predictive model for COVID‐19 diagnosis based on lung ultrasound and clinical features. We used ultrasound to image the lung bilaterally at two anterior sites, one and two hands below each clavicle, and a posterolateral site that was the posterior transverse continuation from the lower anterior site. We studied 100 patients, 31 of whom had a COVID‐19 positive reverse transcriptase polymerase chain reaction. A positive test was independently associated with: quick sequential organ failure assessment score ≥1; ≥3 B‐lines at the upper site; consolidation and thickened pleura at the lower site; and thickened pleura line at the posterolateral site. The model discrimination was an area (95%CI) under the receiver operating characteristic curve of 0.82 (0.75–0.90). The characteristics (95%CI) of the model’s diagnostic threshold, applied to the population from which it was derived, were: sensitivity, 97% (83–100%); specificity, 62% (50–74%); positive predictive value, 54% (41–98%); and negative predictive value, 98% (88–99%). This model may facilitate triage of patients with suspected COVID‐19 infection admitted to the emergency room.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>32520406</pmid><doi>10.1111/anae.15175</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5644-3412</orcidid><orcidid>https://orcid.org/0000-0002-4630-5833</orcidid><orcidid>https://orcid.org/0000-0001-9528-2669</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Area Under Curve Clavicle Cohort Studies Coronavirus Infections - diagnosis Coronavirus Infections - diagnostic imaging COVID-19 Diagnostic systems Emergencies Emergency medical care Emergency Medical Services Emergency Service, Hospital - organization & administration Emergency Service, Hospital - statistics & numerical data Female Humans Infections Life Sciences Lung - diagnostic imaging lung ultrasound Lungs Male Medical imaging Middle Aged Organ Dysfunction Scores Original Pandemics Pleura Pleura - diagnostic imaging Pneumonia, Viral - diagnosis Pneumonia, Viral - diagnostic imaging Polymerase Chain Reaction Prediction models Predictive Value of Tests RNA-directed DNA polymerase ROC Curve Sensitivity and Specificity Triage Ultrasonic imaging Ultrasonography Ultrasound |
title | The association of lung ultrasound images with COVID‐19 infection in an emergency room cohort |
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