Fibronectin extra domain A (FN-EDA) elevates intraocular pressure through Toll-like receptor 4 signaling

Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage, which leads to impaired aqueous humor outflow. Here, we explore a novel molecular mechanism involved in glaucomatous TM damage....

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Veröffentlicht in:	Scientific reports 2020-06, Vol.10 (1), p.9815, Article 9815
Hauptverfasser:	Roberts, Amanda L., Mavlyutov, Timur A., Perlmutter, Tanisha E., Curry, Stacy M., Harris, Sherri L., Chauhan, Anil K., McDowell, Colleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/767/1424 631/80/304 64 64/110 64/60 82/80 Animals Fibronectin Fibronectins - chemistry Fibronectins - metabolism Gene Expression Regulation Glaucoma Humanities and Social Sciences Hypertension Immunohistochemistry Intraocular Pressure Mice Mice, Inbred C57BL multidisciplinary Risk factors Rodents Science Science (multidisciplinary) Signal Transduction TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Trabecular Meshwork - cytology Trabecular Meshwork - metabolism Transforming Growth Factor beta2 - metabolism Transgenic mice
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