Highly reliable, targeted photothermal cancer therapy combined with thermal dosimetry using a near-infrared absorbent
Photothermal therapy (PTT) using a photo-absorbent in the near-infrared (NIR) region is an effective methodology for local cancer treatment. Before PTT using a NIR absorbent is executed, the operator generally determines the two parameters of fluence rate and irradiation time. However, even if the i...
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| Veröffentlicht in: | Scientific reports 2020-06, Vol.10 (1), p.9765, Article 9765 |
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| creator | Nomura, Shinsuke Morimoto, Yuji Tsujimoto, Hironori Arake, Masashi Harada, Manabu Saitoh, Daizoh Hara, Isao Ozeki, Eiichi Satoh, Ayano Takayama, Eiji Hase, Kazuo Kishi, Yoji Ueno, Hideki |
| description | Photothermal therapy (PTT) using a photo-absorbent in the near-infrared (NIR) region is an effective methodology for local cancer treatment. Before PTT using a NIR absorbent is executed, the operator generally determines the two parameters of fluence rate and irradiation time. However, even if the irradiation parameters are unchanged, the therapeutic effect of PTT is often different for individual tumors. Hence, we examined the therapeutic effect of PTT using a NIR absorbent (ICG lactosome) while changing two parameters (fluence rate and irradiation time) in various combinations. As a result, there was no robust correlation between those parameters and the therapeutic effect. Compared to those parameters, we found that a more reliable determinant was maintenance of the tumor temperature above 43 °C during NIR irradiation. To reconfirm the significance of the determinant, we developed a new system that can regulate the temperature at the NIR irradiation site at a constant level. By using the new system, we verified the treatment outcomes for tumors in which the NIR absorbent had accumulated. All of the tumors that had been kept at 43 °C during NIR irradiation were cured, while none of the tumors that had been kept at a temperature below 41 °C were cured. In conclusion, PTT using a NIR absorbent with thermal dosimetry is a highly reliable treatment for cancer. |
| doi_str_mv | 10.1038/s41598-020-66646-x |
| format | Article |
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Before PTT using a NIR absorbent is executed, the operator generally determines the two parameters of fluence rate and irradiation time. However, even if the irradiation parameters are unchanged, the therapeutic effect of PTT is often different for individual tumors. Hence, we examined the therapeutic effect of PTT using a NIR absorbent (ICG lactosome) while changing two parameters (fluence rate and irradiation time) in various combinations. As a result, there was no robust correlation between those parameters and the therapeutic effect. Compared to those parameters, we found that a more reliable determinant was maintenance of the tumor temperature above 43 °C during NIR irradiation. To reconfirm the significance of the determinant, we developed a new system that can regulate the temperature at the NIR irradiation site at a constant level. By using the new system, we verified the treatment outcomes for tumors in which the NIR absorbent had accumulated. All of the tumors that had been kept at 43 °C during NIR irradiation were cured, while none of the tumors that had been kept at a temperature below 41 °C were cured. In conclusion, PTT using a NIR absorbent with thermal dosimetry is a highly reliable treatment for cancer.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-66646-x</identifier><identifier>PMID: 32555349</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/57 ; 631/61 ; 631/67 ; 692/4028 ; Absorbents ; Animals ; Apoptosis ; Cancer ; Cancer therapies ; Cell Proliferation ; Colonic Neoplasms - pathology ; Colonic Neoplasms - therapy ; Combined Modality Therapy ; Dosimetry ; Female ; Humanities and Social Sciences ; Humans ; Hyperthermia, Induced - methods ; I.R. radiation ; Indocyanine Green - chemistry ; Infrared Rays ; Irradiation ; Mice ; Mice, Inbred BALB C ; multidisciplinary ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Phototherapy - methods ; Science ; Science (multidisciplinary) ; Tumor Cells, Cultured ; Tumors ; Xenograft Model Antitumor Assays</subject><ispartof>Scientific reports, 2020-06, Vol.10 (1), p.9765, Article 9765</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-a2f706a7fadd6d8173ca754875f6031e4d319bcabd918e85426a8dfe2591b8373</citedby><cites>FETCH-LOGICAL-c474t-a2f706a7fadd6d8173ca754875f6031e4d319bcabd918e85426a8dfe2591b8373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299938/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299938/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,41118,42187,51574,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32555349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nomura, Shinsuke</creatorcontrib><creatorcontrib>Morimoto, Yuji</creatorcontrib><creatorcontrib>Tsujimoto, Hironori</creatorcontrib><creatorcontrib>Arake, Masashi</creatorcontrib><creatorcontrib>Harada, Manabu</creatorcontrib><creatorcontrib>Saitoh, Daizoh</creatorcontrib><creatorcontrib>Hara, Isao</creatorcontrib><creatorcontrib>Ozeki, Eiichi</creatorcontrib><creatorcontrib>Satoh, Ayano</creatorcontrib><creatorcontrib>Takayama, Eiji</creatorcontrib><creatorcontrib>Hase, Kazuo</creatorcontrib><creatorcontrib>Kishi, Yoji</creatorcontrib><creatorcontrib>Ueno, Hideki</creatorcontrib><title>Highly reliable, targeted photothermal cancer therapy combined with thermal dosimetry using a near-infrared absorbent</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Photothermal therapy (PTT) using a photo-absorbent in the near-infrared (NIR) region is an effective methodology for local cancer treatment. Before PTT using a NIR absorbent is executed, the operator generally determines the two parameters of fluence rate and irradiation time. However, even if the irradiation parameters are unchanged, the therapeutic effect of PTT is often different for individual tumors. Hence, we examined the therapeutic effect of PTT using a NIR absorbent (ICG lactosome) while changing two parameters (fluence rate and irradiation time) in various combinations. As a result, there was no robust correlation between those parameters and the therapeutic effect. Compared to those parameters, we found that a more reliable determinant was maintenance of the tumor temperature above 43 °C during NIR irradiation. To reconfirm the significance of the determinant, we developed a new system that can regulate the temperature at the NIR irradiation site at a constant level. By using the new system, we verified the treatment outcomes for tumors in which the NIR absorbent had accumulated. All of the tumors that had been kept at 43 °C during NIR irradiation were cured, while none of the tumors that had been kept at a temperature below 41 °C were cured. In conclusion, PTT using a NIR absorbent with thermal dosimetry is a highly reliable treatment for cancer.</description><subject>631/57</subject><subject>631/61</subject><subject>631/67</subject><subject>692/4028</subject><subject>Absorbents</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell Proliferation</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Neoplasms - therapy</subject><subject>Combined Modality Therapy</subject><subject>Dosimetry</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>I.R. radiation</subject><subject>Indocyanine Green - chemistry</subject><subject>Infrared Rays</subject><subject>Irradiation</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>multidisciplinary</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - 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Before PTT using a NIR absorbent is executed, the operator generally determines the two parameters of fluence rate and irradiation time. However, even if the irradiation parameters are unchanged, the therapeutic effect of PTT is often different for individual tumors. Hence, we examined the therapeutic effect of PTT using a NIR absorbent (ICG lactosome) while changing two parameters (fluence rate and irradiation time) in various combinations. As a result, there was no robust correlation between those parameters and the therapeutic effect. Compared to those parameters, we found that a more reliable determinant was maintenance of the tumor temperature above 43 °C during NIR irradiation. To reconfirm the significance of the determinant, we developed a new system that can regulate the temperature at the NIR irradiation site at a constant level. By using the new system, we verified the treatment outcomes for tumors in which the NIR absorbent had accumulated. All of the tumors that had been kept at 43 °C during NIR irradiation were cured, while none of the tumors that had been kept at a temperature below 41 °C were cured. In conclusion, PTT using a NIR absorbent with thermal dosimetry is a highly reliable treatment for cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32555349</pmid><doi>10.1038/s41598-020-66646-x</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/57 631/61 631/67 692/4028 Absorbents Animals Apoptosis Cancer Cancer therapies Cell Proliferation Colonic Neoplasms - pathology Colonic Neoplasms - therapy Combined Modality Therapy Dosimetry Female Humanities and Social Sciences Humans Hyperthermia, Induced - methods I.R. radiation Indocyanine Green - chemistry Infrared Rays Irradiation Mice Mice, Inbred BALB C multidisciplinary Nanoparticles - administration & dosage Nanoparticles - chemistry Phototherapy - methods Science Science (multidisciplinary) Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays |
| title | Highly reliable, targeted photothermal cancer therapy combined with thermal dosimetry using a near-infrared absorbent |
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