A Quantitative Centrosomal Amplification Score Predicts Local Recurrence of Ductal Carcinoma In Situ

The purpose of this study is to predict risk of local recurrence (LR) in ductal carcinoma (DCIS) with a new visualization and quantification approach using centrosome amplification (CA), a cancer cell-specific trait widely associated with aggressiveness. This first-of-its-kind methodology evaluates...

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Veröffentlicht in:	Clinical cancer research 2020-06, Vol.26 (12), p.2898-2907
Hauptverfasser:	Mittal, Karuna, Toss, Michael S, Wei, Guanhao, Kaur, Jaspreet, Choi, Da Hoon, Melton, Brian D, Osan, Remus M, Miligy, Islam M, Green, Andrew R, Janssen, Emiel A M, Søiland, Håvard, Gogineni, Keerthi, Manne, Upender, Rida, Padmashree, Rakha, Emad A, Aneja, Ritu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - therapy Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - pathology Carcinoma, Intraductal, Noninfiltrating - therapy Centrosome Combined Modality Therapy Female Follow-Up Studies Gene Amplification Humans Mastectomy, Segmental - methods Middle Aged Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - therapy Prognosis Radiotherapy, Adjuvant - methods Retrospective Studies Survival Rate
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