Rb and p53-Deficient Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma Require Skp2 for Survival

Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are highly genetically complex soft tissue sarcomas. Up to 50% of patients develop distant metastases, but current systemic therapies have limited efficacy. MFS and UPS have recently been shown to commonly harbor copy number alter...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2020-06, Vol.80 (12), p.2461-2471
Hauptverfasser:	Li, George Z, Okada, Tomoyo, Kim, Young-Mi, Agaram, Narasimhan P, Sanchez-Vega, Francisco, Shen, Yawei, Tsubokawa, Norifumi, Rios, Jordan, Martin, Axel S, Dickson, Mark A, Qin, Li-Xuan, Socci, Nicholas D, Singer, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Comparative Genomic Hybridization Fibrosarcoma - genetics Humans Mice Sarcoma - genetics Soft Tissue Neoplasms Tumor Suppressor Protein p53 - genetics
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