Cooperative effects of galanin and leptin on alleviation of insulin resistance in adipose tissue of diabetic rats

It was reported that either orexigenic neuropeptide galanin or anorexigenic hormone leptin caught benefit insulin sensitivity through increasing the translocation of glucose transporter 4 (GLUT4) in patients with diabetes. To date, it is unknown whether galanin can potentiate the effect of leptin on...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-06, Vol.24 (12), p.6773-6780
Hauptverfasser:	Le, Bu, Cheng, Xiaoyun, Qu, Shen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - metabolism Adiponectin Adiponectin - blood Adipose tissue Adipose Tissue - drug effects Adipose Tissue - pathology Akt AKT protein Animals Body fat Body Weight - drug effects Deoxyglucose - metabolism Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - pathology diabetic models Experiments Feeding Behavior - drug effects Food Galanin Galanin - pharmacology Gene expression Glucose Glucose Clamp Technique Glucose transporter Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism GLUT4 Homeostasis Hormones Hyperinsulinism - blood Hyperinsulinism - complications Hypothalamus Insulin Insulin Resistance Leptin Leptin - pharmacology Localization Male Membranes Metabolism Original Phosphorylation Phosphorylation - drug effects Plasma Proteins Proto-Oncogene Proteins c-akt - metabolism Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism Rodents
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