Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-recovered participants, developed neutralization assays to investigate antibody responses, adapted our high-thro...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2020-08, Vol.369 (6506), p.956-963
Hauptverfasser:	Rogers, Thomas F, Zhao, Fangzhu, Huang, Deli, Beutler, Nathan, Burns, Alison, He, Wan-Ting, Limbo, Oliver, Smith, Chloe, Song, Ge, Woehl, Jordan, Yang, Linlin, Abbott, Robert K, Callaghan, Sean, Garcia, Elijah, Hurtado, Jonathan, Parren, Mara, Peng, Linghang, Ramirez, Sydney, Ricketts, James, Ricciardi, Michael J, Rawlings, Stephen A, Wu, Nicholas C, Yuan, Meng, Smith, Davey M, Nemazee, David, Teijaro, John R, Voss, James E, Wilson, Ian A, Andrabi, Raiees, Briney, Bryan, Landais, Elise, Sok, Devin, Jardine, Joseph G, Burton, Dennis R
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Adult Angiotensin Angiotensin-Converting Enzyme 2 Animal diseases Animal models Animals Antibodies Antibodies, Monoclonal - blood Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification Antibodies, Monoclonal - therapeutic use Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Neutralizing - isolation & purification Antibodies, Neutralizing - therapeutic use Antibodies, Viral - blood Antibodies, Viral - immunology Antibodies, Viral - isolation & purification Antibodies, Viral - therapeutic use Antibody Affinity Antibody Specificity Betacoronavirus - immunology Betacoronavirus - physiology Binding Sites Cell Line Coronaviridae Coronavirus Infections - immunology Coronavirus Infections - prevention & control Coronavirus Infections - therapy Coronavirus Infections - virology Coronaviruses COVID-19 COVID-19 Serotherapy Disease Models, Animal Domains Epitopes Female Global health Hamsters Humans Immunization, Passive Immunology Lung - virology Male Mesocricetus Microbio Middle Aged Model testing Monoclonal antibodies Neutralization Neutralization Tests Neutralizing Pandemics - prevention & control Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - immunology Pneumonia, Viral - prevention & control Pneumonia, Viral - therapy Pneumonia, Viral - virology Prophylaxis Protein Domains Proteins Receptors Respiratory diseases SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism Spike protein Vaccines Viral diseases Viral Load Virus Replication
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