Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion
Clinical evidence suggests that patients with subcortical ischemic vascular dementia (SIVD) perform better at cognitive tests after exercise. However, the underlying mechanism for this effect is largely unknown. Here, we examined how treadmill exercise changes the cognitive function and white matter...
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| Veröffentlicht in: | Translational stroke research 2020-06, Vol.11 (3), p.496-502 |
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| creator | Ohtomo, Ryo Kinoshita, Keita Ohtomo, Gaku Takase, Hajime Hamanaka, Gen Washida, Kazuo Islam, Mohammad Rashedul Wrann, Christiane D. Katsuki, Hiroshi Iwata, Atsushi Lok, Josephine Lo, Eng H. Arai, Ken |
| description | Clinical evidence suggests that patients with subcortical ischemic vascular dementia (SIVD) perform better at cognitive tests after exercise. However, the underlying mechanism for this effect is largely unknown. Here, we examined how treadmill exercise changes the cognitive function and white matter cellular pathology in a mouse model of SIVD. Prolonged cerebral hypoperfusion was induced in 2-month-old male C57BL/6J mice by bilateral common carotid artery stenosis. A week later, the mice were randomly divided into a group that received 6-week treadmill exercise and a sedentary group for observation. In multiple behavioral tests (Y-maze, novel object recognition, and Morris water maze tests), the treadmill exercise training was shown to ameliorate cognitive decline in the hypoperfused SIVD mice. In addition, immunohistological analyses confirmed that there was a larger population of oligodendrocyte precursor cells in the subventricular zone of exercised versus sedentary mice. Although further investigations are needed to confirm a causal link between these findings, our study establishes a model and cellular foundation for investigating the mechanisms through which exercise preserves cognitive function in SIVD. |
| doi_str_mv | 10.1007/s12975-019-00734-7 |
| format | Article |
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Stroke Res</addtitle><addtitle>Transl Stroke Res</addtitle><description>Clinical evidence suggests that patients with subcortical ischemic vascular dementia (SIVD) perform better at cognitive tests after exercise. However, the underlying mechanism for this effect is largely unknown. Here, we examined how treadmill exercise changes the cognitive function and white matter cellular pathology in a mouse model of SIVD. Prolonged cerebral hypoperfusion was induced in 2-month-old male C57BL/6J mice by bilateral common carotid artery stenosis. A week later, the mice were randomly divided into a group that received 6-week treadmill exercise and a sedentary group for observation. In multiple behavioral tests (Y-maze, novel object recognition, and Morris water maze tests), the treadmill exercise training was shown to ameliorate cognitive decline in the hypoperfused SIVD mice. In addition, immunohistological analyses confirmed that there was a larger population of oligodendrocyte precursor cells in the subventricular zone of exercised versus sedentary mice. Although further investigations are needed to confirm a causal link between these findings, our study establishes a model and cellular foundation for investigating the mechanisms through which exercise preserves cognitive function in SIVD.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiology</subject><subject>Dementia</subject><subject>Exercise</subject><subject>Fitness equipment</subject><subject>Mann-Whitney U test</subject><subject>Memory</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Physical fitness</subject><subject>Short Communication</subject><subject>Surgery</subject><subject>Variance analysis</subject><subject>Vascular Surgery</subject><issn>1868-4483</issn><issn>1868-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpVkctuEzEUhi0EolXpC7BAllgP-BZfNkgoFFqpUZEogp3lGZ-krhx7sGcq8jR91bok3OyFL__n_xz5R-glJW8oIeptpcyoRUeo6dqRi049QcdUS91JQr8_PeyF0PwIndZ6S9rgVEjBn6MjTiWRWutjdH9dwPltiBGf_YQyhAr4yzyOBWqFipd5k8IU7gB_gCGGBNgljy_S0F496t9uwgR45aYJCr6KYZM9JF_ysGvXnwsMc6m54CXEWHFI2OFVnluJVeMizuvG5JjTBnxjCvTFRXy-G_MIZT3XkNML9GztYoXTw3qCvn48u16ed5dXny6W7y-7kfHF1DkGIJVx0njNgfWeKM2kWsCgzEIoJpSX_ZorTXqte80cFcz5XhrdJvcDP0Hv9r7j3G_BD5Cm1osdS9i6srPZBfu_ksKN3eQ7q5jRUppm8PpgUPKPGepkb_NcUuvZMsMIV5IJ2ahX_5b54_87kAbwPVCb1P6l_LWhxD4mb_fJ25a8_ZW8VfwBRFOieA</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Ohtomo, Ryo</creator><creator>Kinoshita, Keita</creator><creator>Ohtomo, Gaku</creator><creator>Takase, Hajime</creator><creator>Hamanaka, Gen</creator><creator>Washida, Kazuo</creator><creator>Islam, Mohammad Rashedul</creator><creator>Wrann, Christiane D.</creator><creator>Katsuki, Hiroshi</creator><creator>Iwata, Atsushi</creator><creator>Lok, Josephine</creator><creator>Lo, Eng H.</creator><creator>Arai, Ken</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1615-3258</orcidid></search><sort><creationdate>20200601</creationdate><title>Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion</title><author>Ohtomo, Ryo ; Kinoshita, Keita ; Ohtomo, Gaku ; Takase, Hajime ; Hamanaka, Gen ; Washida, Kazuo ; Islam, Mohammad Rashedul ; Wrann, Christiane D. ; Katsuki, Hiroshi ; Iwata, Atsushi ; Lok, Josephine ; Lo, Eng H. ; Arai, Ken</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-a2ee679a69d83e2bd0782675ec79547247d6bf3780b88b82a142adb6989893dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiology</topic><topic>Dementia</topic><topic>Exercise</topic><topic>Fitness equipment</topic><topic>Mann-Whitney U test</topic><topic>Memory</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Physical fitness</topic><topic>Short Communication</topic><topic>Surgery</topic><topic>Variance analysis</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohtomo, Ryo</creatorcontrib><creatorcontrib>Kinoshita, Keita</creatorcontrib><creatorcontrib>Ohtomo, Gaku</creatorcontrib><creatorcontrib>Takase, Hajime</creatorcontrib><creatorcontrib>Hamanaka, Gen</creatorcontrib><creatorcontrib>Washida, Kazuo</creatorcontrib><creatorcontrib>Islam, Mohammad Rashedul</creatorcontrib><creatorcontrib>Wrann, Christiane D.</creatorcontrib><creatorcontrib>Katsuki, Hiroshi</creatorcontrib><creatorcontrib>Iwata, Atsushi</creatorcontrib><creatorcontrib>Lok, Josephine</creatorcontrib><creatorcontrib>Lo, Eng H.</creatorcontrib><creatorcontrib>Arai, Ken</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational stroke research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohtomo, Ryo</au><au>Kinoshita, Keita</au><au>Ohtomo, Gaku</au><au>Takase, Hajime</au><au>Hamanaka, Gen</au><au>Washida, Kazuo</au><au>Islam, Mohammad Rashedul</au><au>Wrann, Christiane D.</au><au>Katsuki, Hiroshi</au><au>Iwata, Atsushi</au><au>Lok, Josephine</au><au>Lo, Eng H.</au><au>Arai, Ken</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion</atitle><jtitle>Translational stroke research</jtitle><stitle>Transl. Stroke Res</stitle><addtitle>Transl Stroke Res</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>11</volume><issue>3</issue><spage>496</spage><epage>502</epage><pages>496-502</pages><issn>1868-4483</issn><eissn>1868-601X</eissn><abstract>Clinical evidence suggests that patients with subcortical ischemic vascular dementia (SIVD) perform better at cognitive tests after exercise. However, the underlying mechanism for this effect is largely unknown. Here, we examined how treadmill exercise changes the cognitive function and white matter cellular pathology in a mouse model of SIVD. Prolonged cerebral hypoperfusion was induced in 2-month-old male C57BL/6J mice by bilateral common carotid artery stenosis. A week later, the mice were randomly divided into a group that received 6-week treadmill exercise and a sedentary group for observation. 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| subjects | Biomedical and Life Sciences Biomedicine Cardiology Dementia Exercise Fitness equipment Mann-Whitney U test Memory Neurology Neurosciences Neurosurgery Physical fitness Short Communication Surgery Variance analysis Vascular Surgery |
| title | Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion |
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