RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells

During angiogenesis, VEGF acts as an attractive cue for endothelial cells (ECs), while Sema3E mediates repulsive cues. Here, we show that the small GTPase RhoJ integrates these opposing signals in directional EC migration. In the GTP‐bound state, RhoJ interacts with the cytoplasmic domain of PlexinD...

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Veröffentlicht in:	The EMBO journal 2020-06, Vol.39 (12), p.e102930-n/a
Hauptverfasser:	Fukushima, Yoko, Nishiyama, Koichi, Kataoka, Hiroshi, Fruttiger, Marcus, Fukuhara, Shigetomo, Nishida, Kohji, Mochizuki, Naoki, Kurihara, Hiroki, Nishikawa, Shin‐Ichi, Uemura, Akiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AKT protein Angiogenesis Animals Cell adhesion & migration Cell migration Cell Movement Contractility Contraction Degradation directional cell migration EMBO37 EMBO46 endothelial cell Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Guanosine diphosphate Guanosine triphosphatases Guanosine triphosphate Human Umbilical Vein Endothelial Cells Humans Integrators Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Ischemia MAP kinase Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Transgenic Neuropilin Regeneration Retina rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism RhoJ Sema3E Signal Transduction Signaling Stimulation Therapeutic applications Tissue engineering Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF
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