Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?
In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is...
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| Veröffentlicht in: | European journal of pharmacology 2020-09, Vol.882, p.173288-173288, Article 173288 |
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| creator | Sureda, Antoni Alizadeh, Javad Nabavi, Seyed Fazel Berindan-Neagoe, Ioana Cismaru, Cosmin Andrei Jeandet, Philippe Łos, Marek J. Clementi, Emilio Nabavi, Seyed Mohammad Ghavami, Saeid |
| description | In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection. |
| doi_str_mv | 10.1016/j.ejphar.2020.173288 |
| format | Article |
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Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection.</description><identifier>ISSN: 0014-2999</identifier><identifier>ISSN: 1879-0712</identifier><identifier>EISSN: 1879-0712</identifier><identifier>EISSN: 0014-2999</identifier><identifier>DOI: 10.1016/j.ejphar.2020.173288</identifier><identifier>PMID: 32561291</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alveolar Epithelial Cells - cytology ; Alveolar Epithelial Cells - drug effects ; Alveolar Epithelial Cells - metabolism ; Alveolar Epithelial Cells - virology ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus - metabolism ; Clathrin-Coated Vesicles - drug effects ; Clathrin-Coated Vesicles - metabolism ; Coronavirus Infections - drug therapy ; Coronavirus Infections - virology ; COVID-19 ; Endocytosis - drug effects ; Endoplasmic reticulum ; Endoplasmic Reticulum - drug effects ; Endoplasmic Reticulum - metabolism ; Endosomes - drug effects ; Endosomes - metabolism ; Humans ; Ionophores - pharmacology ; Ionophores - therapeutic use ; IRE1 ; Life Sciences ; Pandemics ; Peptidyl-Dipeptidase A - metabolism ; PERK ; Pneumonia, Viral - drug therapy ; Pneumonia, Viral - virology ; SARS-CoV-2 ; Spliced XBP1 ; Unfolded protein response ; Unfolded Protein Response - drug effects</subject><ispartof>European journal of pharmacology, 2020-09, Vol.882, p.173288-173288, Article 173288</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2020 Elsevier B.V. All rights reserved. 2020 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-79faff7945a42acec7b1853c2b3d2341fdbfabed95dbcb54872863f872ec3a123</citedby><cites>FETCH-LOGICAL-c497t-79faff7945a42acec7b1853c2b3d2341fdbfabed95dbcb54872863f872ec3a123</cites><orcidid>0000-0003-3023-4871</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014299920303800$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32561291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-reims.fr/hal-03114786$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Sureda, Antoni</creatorcontrib><creatorcontrib>Alizadeh, Javad</creatorcontrib><creatorcontrib>Nabavi, Seyed Fazel</creatorcontrib><creatorcontrib>Berindan-Neagoe, Ioana</creatorcontrib><creatorcontrib>Cismaru, Cosmin Andrei</creatorcontrib><creatorcontrib>Jeandet, Philippe</creatorcontrib><creatorcontrib>Łos, Marek J.</creatorcontrib><creatorcontrib>Clementi, Emilio</creatorcontrib><creatorcontrib>Nabavi, Seyed Mohammad</creatorcontrib><creatorcontrib>Ghavami, Saeid</creatorcontrib><title>Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection.</description><subject>Alveolar Epithelial Cells - cytology</subject><subject>Alveolar Epithelial Cells - drug effects</subject><subject>Alveolar Epithelial Cells - metabolism</subject><subject>Alveolar Epithelial Cells - virology</subject><subject>Angiotensin-Converting Enzyme 2</subject><subject>Betacoronavirus - metabolism</subject><subject>Clathrin-Coated Vesicles - drug effects</subject><subject>Clathrin-Coated Vesicles - metabolism</subject><subject>Coronavirus Infections - drug therapy</subject><subject>Coronavirus Infections - virology</subject><subject>COVID-19</subject><subject>Endocytosis - drug effects</subject><subject>Endoplasmic reticulum</subject><subject>Endoplasmic Reticulum - drug effects</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>Endosomes - drug effects</subject><subject>Endosomes - metabolism</subject><subject>Humans</subject><subject>Ionophores - pharmacology</subject><subject>Ionophores - therapeutic use</subject><subject>IRE1</subject><subject>Life Sciences</subject><subject>Pandemics</subject><subject>Peptidyl-Dipeptidase A - metabolism</subject><subject>PERK</subject><subject>Pneumonia, Viral - drug therapy</subject><subject>Pneumonia, Viral - virology</subject><subject>SARS-CoV-2</subject><subject>Spliced XBP1</subject><subject>Unfolded protein response</subject><subject>Unfolded Protein Response - drug effects</subject><issn>0014-2999</issn><issn>1879-0712</issn><issn>1879-0712</issn><issn>0014-2999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVpaLZp_0EpuvbgrT5sy7o0hJCPwkIv6aUXMZZGu1psy8jehfz7aHGTtjn0NDAz7zsfDyGfOFtzxuuv-zXuxx2ktWAip5QUTfOGrHijdMEUF2_JijFeFkJrfU7eT9OeMVZpUb0j51JUNRear8ivm8HFsYOpD5YmnIM9dIeewkSBjnHGYQ7Q0XmHCUY85DKdIW1xpj4mauMxuIJrGgaPdg5xoD0MsMU-6y4_kDMP3YQff8cL8vP25uH6vtj8uPt-fbUpbKnVXCjtwXulywpKARatanlTSSta6YQsuXethxadrlxr26pslGhq6XNAK4ELeUG-Lb7joe3R2Tw7QWfGFHpIjyZCMP9WhrAz23g0SmhVNyeDL4vB7pXs_mpjTjkmOS9VUx957i2XXpviNCX0LwLOzImL2ZuFizlxMQuXLPv8944vomcQf47A_KljwGQmG3Cw6ELKrzUuhv9PeAKZPKLz</recordid><startdate>20200905</startdate><enddate>20200905</enddate><creator>Sureda, Antoni</creator><creator>Alizadeh, Javad</creator><creator>Nabavi, Seyed Fazel</creator><creator>Berindan-Neagoe, Ioana</creator><creator>Cismaru, Cosmin Andrei</creator><creator>Jeandet, Philippe</creator><creator>Łos, Marek J.</creator><creator>Clementi, Emilio</creator><creator>Nabavi, Seyed Mohammad</creator><creator>Ghavami, Saeid</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3023-4871</orcidid></search><sort><creationdate>20200905</creationdate><title>Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?</title><author>Sureda, Antoni ; 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Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32561291</pmid><doi>10.1016/j.ejphar.2020.173288</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3023-4871</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 2020-09, Vol.882, p.173288-173288, Article 173288 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alveolar Epithelial Cells - cytology Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - virology Angiotensin-Converting Enzyme 2 Betacoronavirus - metabolism Clathrin-Coated Vesicles - drug effects Clathrin-Coated Vesicles - metabolism Coronavirus Infections - drug therapy Coronavirus Infections - virology COVID-19 Endocytosis - drug effects Endoplasmic reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endosomes - drug effects Endosomes - metabolism Humans Ionophores - pharmacology Ionophores - therapeutic use IRE1 Life Sciences Pandemics Peptidyl-Dipeptidase A - metabolism PERK Pneumonia, Viral - drug therapy Pneumonia, Viral - virology SARS-CoV-2 Spliced XBP1 Unfolded protein response Unfolded Protein Response - drug effects |
| title | Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management? |
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