Engineering a Proximity-Directed O‑GlcNAc Transferase for Selective Protein O‑GlcNAcylation in Cells

O-Linked β-N-acetylglucosamine (O-GlcNAc) is a monosaccharide that plays an essential role in cellular signaling throughout the nucleocytoplasmic proteome of eukaryotic cells. Strategies for selectively increasing O-GlcNAc levels on a target protein in cells would accelerate studies of this essentia...

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Veröffentlicht in:	ACS chemical biology 2020-04, Vol.15 (4), p.1059-1066
Hauptverfasser:	Ramirez, Daniel H, Aonbangkhen, Chanat, Wu, Hung-Yi, Naftaly, Jeffrey A, Tang, Stephanie, O’Meara, Timothy R, Woo, Christina M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - metabolism Glycosylation HEK293 Cells Humans N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism Protein Engineering Protein Processing, Post-Translational Proteome - chemistry Proteome - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Single-Domain Antibodies - genetics Single-Domain Antibodies - metabolism
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