Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7–9 year old rural Gambian children
Early life exposures are important predictors of adult disease risk. Although the underlying mechanisms are largely unknown, telomere maintenance may be involved. This study investigated the relationship between seasonal differences in parental exposures at time of conception and leukocyte telomere...
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| Veröffentlicht in: | Scientific reports 2020-06, Vol.10 (1), p.9675-9675, Article 9675 |
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| description | Early life exposures are important predictors of adult disease risk. Although the underlying mechanisms are largely unknown, telomere maintenance may be involved. This study investigated the relationship between seasonal differences in parental exposures at time of conception and leukocyte telomere length (LTL) in their offspring. LTL was measured in two cohorts of children aged 2 yrs (N = 487) and 7–9 yrs (N = 218). The association between date of conception and LTL was examined using Fourier regression models, adjusted for age, sex, leukocyte cell composition, and other potential confounders. We observed an effect of season in the older children in all models [likelihood ratio test (LRT) χ²
2
= 7.1, p = 0.03; fully adjusted model]. LTL was greatest in children conceived in September (in the rainy season), and smallest in those conceived in March (in the dry season), with an effect size (LTL peak–nadir) of 0.60 z-scores. No effect of season was evident in the younger children (LRT χ²
2
= 0.87, p = 0.65). The different results obtained for the two cohorts may reflect a delayed effect of season of conception on postnatal telomere maintenance. Alternatively, they may be explained by unmeasured differences in early life exposures, or the increased telomere attrition rate during infancy. |
| doi_str_mv | 10.1038/s41598-020-66729-9 |
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2
= 7.1, p = 0.03; fully adjusted model]. LTL was greatest in children conceived in September (in the rainy season), and smallest in those conceived in March (in the dry season), with an effect size (LTL peak–nadir) of 0.60 z-scores. No effect of season was evident in the younger children (LRT χ²
2
= 0.87, p = 0.65). The different results obtained for the two cohorts may reflect a delayed effect of season of conception on postnatal telomere maintenance. Alternatively, they may be explained by unmeasured differences in early life exposures, or the increased telomere attrition rate during infancy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-66729-9</identifier><identifier>PMID: 32541825</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/136 ; 631/136/7 ; 692/308 ; 692/308/174 ; 692/308/2056 ; 692/308/3187 ; Child ; Child, Preschool ; Children ; Cross-Sectional Studies ; Dry season ; Female ; Fertilization ; Gambia ; Genetic crosses ; Health risks ; Humanities and Social Sciences ; Humans ; Leukocytes - metabolism ; Male ; multidisciplinary ; Offspring ; Rainy season ; Regression Analysis ; Science ; Science (multidisciplinary) ; Seasons ; Telomere - metabolism ; Telomere Shortening ; Telomeres</subject><ispartof>Scientific reports, 2020-06, Vol.10 (1), p.9675-9675, Article 9675</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-13d5ac596566dd8c1d9d99d914970137fe5bd6b0181c74e82ec9deecb48e93113</citedby><cites>FETCH-LOGICAL-c522t-13d5ac596566dd8c1d9d99d914970137fe5bd6b0181c74e82ec9deecb48e93113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295801/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295801/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32541825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maasen, Kim</creatorcontrib><creatorcontrib>James, Philip T.</creatorcontrib><creatorcontrib>Prentice, Andrew M.</creatorcontrib><creatorcontrib>Moore, Sophie E.</creatorcontrib><creatorcontrib>Fall, Caroline H.</creatorcontrib><creatorcontrib>Chandak, Giriraj R.</creatorcontrib><creatorcontrib>Betts, Modupeh</creatorcontrib><creatorcontrib>Silver, Matt J.</creatorcontrib><creatorcontrib>Buxton, Jessica L.</creatorcontrib><title>Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7–9 year old rural Gambian children</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Early life exposures are important predictors of adult disease risk. Although the underlying mechanisms are largely unknown, telomere maintenance may be involved. This study investigated the relationship between seasonal differences in parental exposures at time of conception and leukocyte telomere length (LTL) in their offspring. LTL was measured in two cohorts of children aged 2 yrs (N = 487) and 7–9 yrs (N = 218). The association between date of conception and LTL was examined using Fourier regression models, adjusted for age, sex, leukocyte cell composition, and other potential confounders. We observed an effect of season in the older children in all models [likelihood ratio test (LRT) χ²
2
= 7.1, p = 0.03; fully adjusted model]. LTL was greatest in children conceived in September (in the rainy season), and smallest in those conceived in March (in the dry season), with an effect size (LTL peak–nadir) of 0.60 z-scores. No effect of season was evident in the younger children (LRT χ²
2
= 0.87, p = 0.65). The different results obtained for the two cohorts may reflect a delayed effect of season of conception on postnatal telomere maintenance. Alternatively, they may be explained by unmeasured differences in early life exposures, or the increased telomere attrition rate during infancy.</description><subject>631/136</subject><subject>631/136/7</subject><subject>692/308</subject><subject>692/308/174</subject><subject>692/308/2056</subject><subject>692/308/3187</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cross-Sectional Studies</subject><subject>Dry season</subject><subject>Female</subject><subject>Fertilization</subject><subject>Gambia</subject><subject>Genetic crosses</subject><subject>Health risks</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Offspring</subject><subject>Rainy season</subject><subject>Regression Analysis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Seasons</subject><subject>Telomere - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maasen, Kim</au><au>James, Philip T.</au><au>Prentice, Andrew M.</au><au>Moore, Sophie E.</au><au>Fall, Caroline H.</au><au>Chandak, Giriraj R.</au><au>Betts, Modupeh</au><au>Silver, Matt J.</au><au>Buxton, Jessica L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7–9 year old rural Gambian children</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-06-15</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>9675</spage><epage>9675</epage><pages>9675-9675</pages><artnum>9675</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Early life exposures are important predictors of adult disease risk. Although the underlying mechanisms are largely unknown, telomere maintenance may be involved. This study investigated the relationship between seasonal differences in parental exposures at time of conception and leukocyte telomere length (LTL) in their offspring. LTL was measured in two cohorts of children aged 2 yrs (N = 487) and 7–9 yrs (N = 218). The association between date of conception and LTL was examined using Fourier regression models, adjusted for age, sex, leukocyte cell composition, and other potential confounders. We observed an effect of season in the older children in all models [likelihood ratio test (LRT) χ²
2
= 7.1, p = 0.03; fully adjusted model]. LTL was greatest in children conceived in September (in the rainy season), and smallest in those conceived in March (in the dry season), with an effect size (LTL peak–nadir) of 0.60 z-scores. No effect of season was evident in the younger children (LRT χ²
2
= 0.87, p = 0.65). The different results obtained for the two cohorts may reflect a delayed effect of season of conception on postnatal telomere maintenance. Alternatively, they may be explained by unmeasured differences in early life exposures, or the increased telomere attrition rate during infancy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32541825</pmid><doi>10.1038/s41598-020-66729-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/136 631/136/7 692/308 692/308/174 692/308/2056 692/308/3187 Child Child, Preschool Children Cross-Sectional Studies Dry season Female Fertilization Gambia Genetic crosses Health risks Humanities and Social Sciences Humans Leukocytes - metabolism Male multidisciplinary Offspring Rainy season Regression Analysis Science Science (multidisciplinary) Seasons Telomere - metabolism Telomere Shortening Telomeres |
| title | Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7–9 year old rural Gambian children |
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