Synaptic proteins, neuropathology and cognitive status in the oldest-old

Abstract An increasing number of individuals in our population are surviving to over 90 years and a subset is at risk for developing dementia. However, senile plaque and neurofibrillary tangle pathology do not consistently differentiate individuals with and without dementia. Synaptic protein loss is...

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Veröffentlicht in:	Neurobiology of aging 2009-07, Vol.30 (7), p.1125-1134
Hauptverfasser:	Head, Elizabeth, Corrada, Maria M, Kahle-Wrobleski, Kristin, Kim, Ronald C, Sarsoza, Floyd, Goodus, Matthew, Kawas, Claudia H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Aging - metabolism Aging - pathology Aging - psychology Biological and medical sciences Biomarkers - analysis Biomarkers - metabolism Clinico-pathology correlation Cognition Disorders - metabolism Cognition Disorders - pathology Cognition Disorders - psychology Cognitively impaired not demented Cohort Studies Compensatory response Dementia Dementia - metabolism Dementia - pathology Dementia - psychology Development. Senescence. Regeneration. Transplantation Disease Progression Disks Large Homolog 4 Protein Female Frontal Lobe - metabolism Frontal Lobe - pathology Fundamental and applied biological sciences. Psychology GAP-43 Protein - analysis GAP-43 Protein - metabolism Growth-associated protein-43 (GAP-43) Humans Internal Medicine Intracellular Signaling Peptides and Proteins - analysis Intracellular Signaling Peptides and Proteins - metabolism Male Membrane Proteins - analysis Membrane Proteins - metabolism MMSE Neurology Neuropsychological Tests Oldest-old Postsynaptic density (PSD) Prospective Studies Synaptic Membranes - metabolism Synaptophysin (SYN) Synaptophysin - analysis Synaptophysin - metabolism Vertebrates: nervous system and sense organs
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