Synaptic proteins, neuropathology and cognitive status in the oldest-old
Abstract An increasing number of individuals in our population are surviving to over 90 years and a subset is at risk for developing dementia. However, senile plaque and neurofibrillary tangle pathology do not consistently differentiate individuals with and without dementia. Synaptic protein loss is...
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| Veröffentlicht in: | Neurobiology of aging 2009-07, Vol.30 (7), p.1125-1134 |
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| creator | Head, Elizabeth Corrada, Maria M Kahle-Wrobleski, Kristin Kim, Ronald C Sarsoza, Floyd Goodus, Matthew Kawas, Claudia H |
| description | Abstract An increasing number of individuals in our population are surviving to over 90 years and a subset is at risk for developing dementia. However, senile plaque and neurofibrillary tangle pathology do not consistently differentiate individuals with and without dementia. Synaptic protein loss is a feature of aging and dementia and may dissociate 90+ individuals with and without dementia. Synaptophysin (SYN), postsynaptic density 95 (PSD-95) and growth-associated protein 43 (GAP-43) were studied in the frontal cortex of an autopsy series of 32 prospectively followed individuals (92–105 years) with a range of cognitive function. SYN protein levels were decreased in individuals with dementia and increased in those with clinical signs of cognitive impairment insufficient for a diagnosis of dementia. SYN but neither PSD-95 nor GAP-43 protein levels were significantly correlated with mini-mental status examination (MMSE) scores. Frontal cortex SYN protein levels may protect neuronal function in oldest-old individuals and reflect compensatory responses that may be involved with maintaining cognition. |
| doi_str_mv | 10.1016/j.neurobiolaging.2007.10.001 |
| format | Article |
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However, senile plaque and neurofibrillary tangle pathology do not consistently differentiate individuals with and without dementia. Synaptic protein loss is a feature of aging and dementia and may dissociate 90+ individuals with and without dementia. Synaptophysin (SYN), postsynaptic density 95 (PSD-95) and growth-associated protein 43 (GAP-43) were studied in the frontal cortex of an autopsy series of 32 prospectively followed individuals (92–105 years) with a range of cognitive function. SYN protein levels were decreased in individuals with dementia and increased in those with clinical signs of cognitive impairment insufficient for a diagnosis of dementia. SYN but neither PSD-95 nor GAP-43 protein levels were significantly correlated with mini-mental status examination (MMSE) scores. Frontal cortex SYN protein levels may protect neuronal function in oldest-old individuals and reflect compensatory responses that may be involved with maintaining cognition.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2007.10.001</identifier><identifier>PMID: 18006193</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Aged, 80 and over ; Aging - metabolism ; Aging - pathology ; Aging - psychology ; Biological and medical sciences ; Biomarkers - analysis ; Biomarkers - metabolism ; Clinico-pathology correlation ; Cognition Disorders - metabolism ; Cognition Disorders - pathology ; Cognition Disorders - psychology ; Cognitively impaired not demented ; Cohort Studies ; Compensatory response ; Dementia ; Dementia - metabolism ; Dementia - pathology ; Dementia - psychology ; Development. Senescence. Regeneration. Transplantation ; Disease Progression ; Disks Large Homolog 4 Protein ; Female ; Frontal Lobe - metabolism ; Frontal Lobe - pathology ; Fundamental and applied biological sciences. Psychology ; GAP-43 Protein - analysis ; GAP-43 Protein - metabolism ; Growth-associated protein-43 (GAP-43) ; Humans ; Internal Medicine ; Intracellular Signaling Peptides and Proteins - analysis ; Intracellular Signaling Peptides and Proteins - metabolism ; Male ; Membrane Proteins - analysis ; Membrane Proteins - metabolism ; MMSE ; Neurology ; Neuropsychological Tests ; Oldest-old ; Postsynaptic density (PSD) ; Prospective Studies ; Synaptic Membranes - metabolism ; Synaptophysin (SYN) ; Synaptophysin - analysis ; Synaptophysin - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurobiology of aging, 2009-07, Vol.30 (7), p.1125-1134</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-225ecacc13ad2fb18176b074fe3ba94dd009a0b6b3abc7384d1aa1efb4415283</citedby><cites>FETCH-LOGICAL-c609t-225ecacc13ad2fb18176b074fe3ba94dd009a0b6b3abc7384d1aa1efb4415283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2007.10.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23924533$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18006193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Head, Elizabeth</creatorcontrib><creatorcontrib>Corrada, Maria M</creatorcontrib><creatorcontrib>Kahle-Wrobleski, Kristin</creatorcontrib><creatorcontrib>Kim, Ronald C</creatorcontrib><creatorcontrib>Sarsoza, Floyd</creatorcontrib><creatorcontrib>Goodus, Matthew</creatorcontrib><creatorcontrib>Kawas, Claudia H</creatorcontrib><title>Synaptic proteins, neuropathology and cognitive status in the oldest-old</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract An increasing number of individuals in our population are surviving to over 90 years and a subset is at risk for developing dementia. However, senile plaque and neurofibrillary tangle pathology do not consistently differentiate individuals with and without dementia. Synaptic protein loss is a feature of aging and dementia and may dissociate 90+ individuals with and without dementia. Synaptophysin (SYN), postsynaptic density 95 (PSD-95) and growth-associated protein 43 (GAP-43) were studied in the frontal cortex of an autopsy series of 32 prospectively followed individuals (92–105 years) with a range of cognitive function. SYN protein levels were decreased in individuals with dementia and increased in those with clinical signs of cognitive impairment insufficient for a diagnosis of dementia. SYN but neither PSD-95 nor GAP-43 protein levels were significantly correlated with mini-mental status examination (MMSE) scores. Frontal cortex SYN protein levels may protect neuronal function in oldest-old individuals and reflect compensatory responses that may be involved with maintaining cognition.</description><subject>Aged, 80 and over</subject><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>Aging - psychology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - metabolism</subject><subject>Clinico-pathology correlation</subject><subject>Cognition Disorders - metabolism</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - psychology</subject><subject>Cognitively impaired not demented</subject><subject>Cohort Studies</subject><subject>Compensatory response</subject><subject>Dementia</subject><subject>Dementia - metabolism</subject><subject>Dementia - pathology</subject><subject>Dementia - psychology</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Disease Progression</subject><subject>Disks Large Homolog 4 Protein</subject><subject>Female</subject><subject>Frontal Lobe - metabolism</subject><subject>Frontal Lobe - pathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GAP-43 Protein - analysis</subject><subject>GAP-43 Protein - metabolism</subject><subject>Growth-associated protein-43 (GAP-43)</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Intracellular Signaling Peptides and Proteins - analysis</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Male</subject><subject>Membrane Proteins - analysis</subject><subject>Membrane Proteins - metabolism</subject><subject>MMSE</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Oldest-old</subject><subject>Postsynaptic density (PSD)</subject><subject>Prospective Studies</subject><subject>Synaptic Membranes - metabolism</subject><subject>Synaptophysin (SYN)</subject><subject>Synaptophysin - analysis</subject><subject>Synaptophysin - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9v1DAQxS0EotvCV0A5AKdmGTt_HEuoEqooRarEob1bjjPJesnawXZW2m-Pw64K5QKnOcxvnp_nDSFvKawp0PrDdm1x9q41blSDscOaAfDUWgPQZ2RFq6rJaSn4c7ICKnheVg2ckfMQtpDAktcvyRltAGoqihW5vT9YNUWjs8m7iMaGy-yX_qTixo1uOGTKdpl2gzXR7DELUcU5ZMZmcYOZGzsMMU_lFXnRqzHg61O9IA83nx-ub_O7b1--Xn-6y3UNIuaMVaiV1rRQHetb2lBet8lWj0WrRNl1AEJBW7eFajUvmrKjSlHs27KkFWuKC3J1lJ3mdoedRhu9GuXkzU75g3TKyKcdazZycHvJmagor5LA-5OAdz_mZF7uTNA4jsqim4OsOVueZf8E09prAY1I4McjqL0LwWP_6IaCXCKTW_k0smWWL90UWRp_8-ePfg-fMkrAuxOgglZj75XVJjxyrBCsrIqFuzlymNa_N-hl0Aatxs541FF2zvyvo6u_hPRorElvf8cDhq2bvU0RSyoDkyDvlzNbrgw4QAmMFT8BuiTUzA</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Head, Elizabeth</creator><creator>Corrada, Maria M</creator><creator>Kahle-Wrobleski, Kristin</creator><creator>Kim, Ronald C</creator><creator>Sarsoza, Floyd</creator><creator>Goodus, Matthew</creator><creator>Kawas, Claudia H</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>Synaptic proteins, neuropathology and cognitive status in the oldest-old</title><author>Head, Elizabeth ; Corrada, Maria M ; Kahle-Wrobleski, Kristin ; Kim, Ronald C ; Sarsoza, Floyd ; Goodus, Matthew ; Kawas, Claudia H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-225ecacc13ad2fb18176b074fe3ba94dd009a0b6b3abc7384d1aa1efb4415283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged, 80 and over</topic><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>Aging - psychology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - metabolism</topic><topic>Clinico-pathology correlation</topic><topic>Cognition Disorders - metabolism</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - psychology</topic><topic>Cognitively impaired not demented</topic><topic>Cohort Studies</topic><topic>Compensatory response</topic><topic>Dementia</topic><topic>Dementia - metabolism</topic><topic>Dementia - pathology</topic><topic>Dementia - psychology</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Disease Progression</topic><topic>Disks Large Homolog 4 Protein</topic><topic>Female</topic><topic>Frontal Lobe - metabolism</topic><topic>Frontal Lobe - pathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GAP-43 Protein - analysis</topic><topic>GAP-43 Protein - metabolism</topic><topic>Growth-associated protein-43 (GAP-43)</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Intracellular Signaling Peptides and Proteins - analysis</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Male</topic><topic>Membrane Proteins - analysis</topic><topic>Membrane Proteins - metabolism</topic><topic>MMSE</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Oldest-old</topic><topic>Postsynaptic density (PSD)</topic><topic>Prospective Studies</topic><topic>Synaptic Membranes - metabolism</topic><topic>Synaptophysin (SYN)</topic><topic>Synaptophysin - analysis</topic><topic>Synaptophysin - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Head, Elizabeth</creatorcontrib><creatorcontrib>Corrada, Maria M</creatorcontrib><creatorcontrib>Kahle-Wrobleski, Kristin</creatorcontrib><creatorcontrib>Kim, Ronald C</creatorcontrib><creatorcontrib>Sarsoza, Floyd</creatorcontrib><creatorcontrib>Goodus, Matthew</creatorcontrib><creatorcontrib>Kawas, Claudia H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Head, Elizabeth</au><au>Corrada, Maria M</au><au>Kahle-Wrobleski, Kristin</au><au>Kim, Ronald C</au><au>Sarsoza, Floyd</au><au>Goodus, Matthew</au><au>Kawas, Claudia H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synaptic proteins, neuropathology and cognitive status in the oldest-old</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>30</volume><issue>7</issue><spage>1125</spage><epage>1134</epage><pages>1125-1134</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Abstract An increasing number of individuals in our population are surviving to over 90 years and a subset is at risk for developing dementia. However, senile plaque and neurofibrillary tangle pathology do not consistently differentiate individuals with and without dementia. Synaptic protein loss is a feature of aging and dementia and may dissociate 90+ individuals with and without dementia. Synaptophysin (SYN), postsynaptic density 95 (PSD-95) and growth-associated protein 43 (GAP-43) were studied in the frontal cortex of an autopsy series of 32 prospectively followed individuals (92–105 years) with a range of cognitive function. SYN protein levels were decreased in individuals with dementia and increased in those with clinical signs of cognitive impairment insufficient for a diagnosis of dementia. SYN but neither PSD-95 nor GAP-43 protein levels were significantly correlated with mini-mental status examination (MMSE) scores. Frontal cortex SYN protein levels may protect neuronal function in oldest-old individuals and reflect compensatory responses that may be involved with maintaining cognition.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>18006193</pmid><doi>10.1016/j.neurobiolaging.2007.10.001</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurobiology of aging, 2009-07, Vol.30 (7), p.1125-1134 |
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| subjects | Aged, 80 and over Aging - metabolism Aging - pathology Aging - psychology Biological and medical sciences Biomarkers - analysis Biomarkers - metabolism Clinico-pathology correlation Cognition Disorders - metabolism Cognition Disorders - pathology Cognition Disorders - psychology Cognitively impaired not demented Cohort Studies Compensatory response Dementia Dementia - metabolism Dementia - pathology Dementia - psychology Development. Senescence. Regeneration. Transplantation Disease Progression Disks Large Homolog 4 Protein Female Frontal Lobe - metabolism Frontal Lobe - pathology Fundamental and applied biological sciences. Psychology GAP-43 Protein - analysis GAP-43 Protein - metabolism Growth-associated protein-43 (GAP-43) Humans Internal Medicine Intracellular Signaling Peptides and Proteins - analysis Intracellular Signaling Peptides and Proteins - metabolism Male Membrane Proteins - analysis Membrane Proteins - metabolism MMSE Neurology Neuropsychological Tests Oldest-old Postsynaptic density (PSD) Prospective Studies Synaptic Membranes - metabolism Synaptophysin (SYN) Synaptophysin - analysis Synaptophysin - metabolism Vertebrates: nervous system and sense organs |
| title | Synaptic proteins, neuropathology and cognitive status in the oldest-old |
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