Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway

The pathogenesis of cardiac hypertrophy is tightly associated with activation of intracellular hypertrophic signalling pathways, which leads to the synthesis of various proteins. Tripartite motif 10 (TRIM10) is an E3 ligase with important functions in protein quality control. However, its role in ca...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-06, Vol.24 (11), p.6233-6241
Hauptverfasser:	Yang, Hui, Wang, Xiao‐Xiao, Zhou, Chun‐Yu, Xiao, Xue, Tian, Cui, Li, Hui‐Hua, Yin, Chun‐Lin, Wang, Hong‐Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT AKT protein Animals Antibodies Aorta Aorta - pathology Apoptosis Cardiac hypertrophy Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomyocytes Cell cycle Constriction, Pathologic Gene expression Heart Hypertrophy Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - metabolism Intracellular signalling Mice, Inbred C57BL Mice, Knockout Neonates Original Phenylephrine Phosphorylation Proteins Proteolysis Proto-Oncogene Proteins c-akt - metabolism PTEN PTEN Phosphohydrolase - metabolism PTEN protein Quality control Rats Rats, Sprague-Dawley Rodents Signal Transduction Software STAT3 Transcription Factor - metabolism Statistical analysis Surgery Tensin Transverse aortic constriction TRIM10 Tripartite Motif Proteins - deficiency Tripartite Motif Proteins - metabolism Ubiquitin-protein ligase Ubiquitination
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