Uptake of high-density lipoprotein by scavenger receptor class B type 1 is associated with prostate cancer proliferation and tumor progression in mice

High-density lipoprotein (HDL) metabolism is facilitated in part by scavenger receptor class B, type 1 (SR-B1) that mediates HDL uptake into cells. Higher levels of HDL have been associated with protection in other diseases, however, its role in prostate cancer is not definitive. SR-B1 is up-regulat...

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Veröffentlicht in:	The Journal of biological chemistry 2020-06, Vol.295 (24), p.8252-8261
Hauptverfasser:	Traughber, C. Alicia, Opoku, Emmanuel, Brubaker, Gregory, Major, Jennifer, Lu, Hanxu, Lorkowski, Shuhui Wang, Neumann, Chase, Hardaway, Aimalie, Chung, Yoon-Mi, Gulshan, Kailash, Sharifi, Nima, Brown, J. Mark, Smith, Jonathan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Proliferation Cholesterol - metabolism CRISPR/Cas Disease Progression Gene Expression Regulation, Neoplastic high-density lipoprotein (HDL) Humans Lipids lipoprotein metabolism lipoprotein receptor Lipoproteins, HDL - metabolism Male Mice, Inbred C57BL prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology SCARB1 scavenger receptor scavenger receptor class B, type 1 Scavenger Receptors, Class B - metabolism Up-Regulation - genetics
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