Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in the prevention of venous thromboembolism

Anticoagulant plasma concentrations and patient characteristics might affect the benefit–risk balance of therapy. The study objective was to assess the impact of model-predicted rivaroxaban exposure and patient characteristics on outcomes in patients receiving rivaroxaban for venous thromboembolism...

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Veröffentlicht in:	Journal of thrombosis and thrombolysis 2020-07, Vol.50 (1), p.12-19
Hauptverfasser:	Reinecke, Isabel, Solms, Alexander, Willmann, Stefan, Spiro, Theodore E., Peters, Gary, Weitz, Jeffrey I., Mueck, Wolfgang, Garmann, Dirk, Schmidt, Stephan, Zhang, Liping, Fox, Keith A. A., Berkowitz, Scott D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants Anticoagulants - administration & dosage Anticoagulants - adverse effects Anticoagulants - blood Arthroplasty, Replacement, Hip - adverse effects Biomarkers, Pharmacological - analysis Bleeding Cardiology Chemoprevention - methods Drug Monitoring - methods Drug Monitoring - statistics & numerical data Female Hematology Hemorrhage - chemically induced Hemorrhage - prevention & control Humans Male Medicine Medicine & Public Health Middle Aged Models, Statistical Postoperative Complications - blood Postoperative Complications - diagnosis Postoperative Complications - prevention & control Prognosis Prophylaxis Prothrombin Prothrombin Time - methods Risk Adjustment - methods Risk Assessment Rivaroxaban - administration & dosage Rivaroxaban - adverse effects Rivaroxaban - blood Surgery Thromboembolism Venous Thromboembolism - blood Venous Thromboembolism - diagnosis Venous Thromboembolism - etiology Venous Thromboembolism - prevention & control
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