Medications and in-hospital outcomes in infants born at 22–24 weeks of gestation
Objective To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22–24 weeks of gestation. Study design Multicenter retrospective cohort study of infants born 22–24 weeks of gestation (2006–2016), without major congenital anomalies and with available...
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| Veröffentlicht in: | Journal of perinatology 2020-05, Vol.40 (5), p.781-789 |
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| container_title | Journal of perinatology |
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| creator | Puia-Dumitrescu, Mihai Younge, Noelle Benjamin, Daniel K. Lawson, Katie Hume, Cordelia Hill, Kennedy Mengistu, Jonathan Wilson, Aryeona Zimmerman, Kanecia O. Ahmad, Kaashif Greenberg, Rachel G. |
| description | Objective
To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22–24 weeks of gestation.
Study design
Multicenter retrospective cohort study of infants born 22–24 weeks of gestation (2006–2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group.
Results
This study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016).
Conclusions
A large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period. |
| doi_str_mv | 10.1038/s41372-020-0614-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7293630</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A621910886</galeid><sourcerecordid>A621910886</sourcerecordid><originalsourceid>FETCH-LOGICAL-c662t-861453d2e64cc108fe75dd037f938bf223be1d685d92201cc6711714f492f3553</originalsourceid><addsrcrecordid>eNp9UtuKFDEQDaK44-oH-CINgvjSa1K59ouwLOsFVgTR55BJJzNZu5Ox072yb_6Df-iXmJ5Z1xlRSSBQdepU1clB6DHBJwRT9SIzQiXUGHCNBWE1u4MWhElRc87oXbTAktFaUSaO0IOcLzGek_I-OqKAhVCMLtCHd64N1owhxVyZ2FYh1uuUN2E0XZWm0abe5RIs15s45mqZhliZsQL48e07sOqrc59zlXy1cnnc8jxE97zpsnt08x6jT6_OP569qS_ev357dnpRWyFgrFWZmNMWnGDWEqy8k7xtMZW-oWrpAejSkVYo3jYAmFgrJCGSMM8a8JRzeoxe7ng307J3rXVxHEynN0PozXCtkwn6MBPDWq_SlZbQUEFxIXh-QzCkL1MZX_chW9d1Jro0ZQ2US8ZVo0SBPv0DepmmIZb1NMyaUsEV_y-KNowDKNjjWpnO6aJrKtPZubU-FUCaosW248lfUOW0rg82RedDiR8UPNsrWDvTjeucumn7tYdAsgPaIeU8OH8rGcF69pXe-UoXX-nZV5qVmif7Wt9W_DJSAcAOkEsqrtzwe_V_s_4El3rUgA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2394522826</pqid></control><display><type>article</type><title>Medications and in-hospital outcomes in infants born at 22–24 weeks of gestation</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Puia-Dumitrescu, Mihai ; Younge, Noelle ; Benjamin, Daniel K. ; Lawson, Katie ; Hume, Cordelia ; Hill, Kennedy ; Mengistu, Jonathan ; Wilson, Aryeona ; Zimmerman, Kanecia O. ; Ahmad, Kaashif ; Greenberg, Rachel G.</creator><creatorcontrib>Puia-Dumitrescu, Mihai ; Younge, Noelle ; Benjamin, Daniel K. ; Lawson, Katie ; Hume, Cordelia ; Hill, Kennedy ; Mengistu, Jonathan ; Wilson, Aryeona ; Zimmerman, Kanecia O. ; Ahmad, Kaashif ; Greenberg, Rachel G.</creatorcontrib><description>Objective
To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22–24 weeks of gestation.
Study design
Multicenter retrospective cohort study of infants born 22–24 weeks of gestation (2006–2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group.
Results
This study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016).
Conclusions
A large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period.</description><identifier>ISSN: 0743-8346</identifier><identifier>ISSN: 1476-5543</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-020-0614-4</identifier><identifier>PMID: 32066843</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/409 ; 692/700/1720 ; Antibiotics ; Antiinfectives and antibacterials ; Birth Weight ; Congenital anomalies ; Congenital defects ; Drug therapy ; Female ; Gestation ; Gestational Age ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Infants ; Infants (Premature) ; Intensive care ; Intensive care units ; Intensive Care Units, Neonatal ; Medicine ; Medicine & Public Health ; Methods ; Morbidity ; Neonatal care ; Neonatal intensive care ; Neonates ; Patient outcomes ; Pediatric research ; Pediatric Surgery ; Pediatrics ; Population studies ; Pregnancy ; Retrospective Studies ; Survival</subject><ispartof>Journal of perinatology, 2020-05, Vol.40 (5), p.781-789</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2020</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c662t-861453d2e64cc108fe75dd037f938bf223be1d685d92201cc6711714f492f3553</citedby><cites>FETCH-LOGICAL-c662t-861453d2e64cc108fe75dd037f938bf223be1d685d92201cc6711714f492f3553</cites><orcidid>0000-0002-7847-5204 ; 0000-0003-4156-8543</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-020-0614-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-020-0614-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32066843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puia-Dumitrescu, Mihai</creatorcontrib><creatorcontrib>Younge, Noelle</creatorcontrib><creatorcontrib>Benjamin, Daniel K.</creatorcontrib><creatorcontrib>Lawson, Katie</creatorcontrib><creatorcontrib>Hume, Cordelia</creatorcontrib><creatorcontrib>Hill, Kennedy</creatorcontrib><creatorcontrib>Mengistu, Jonathan</creatorcontrib><creatorcontrib>Wilson, Aryeona</creatorcontrib><creatorcontrib>Zimmerman, Kanecia O.</creatorcontrib><creatorcontrib>Ahmad, Kaashif</creatorcontrib><creatorcontrib>Greenberg, Rachel G.</creatorcontrib><title>Medications and in-hospital outcomes in infants born at 22–24 weeks of gestation</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22–24 weeks of gestation.
Study design
Multicenter retrospective cohort study of infants born 22–24 weeks of gestation (2006–2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group.
Results
This study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016).
Conclusions
A large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period.</description><subject>692/308/409</subject><subject>692/700/1720</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Birth Weight</subject><subject>Congenital anomalies</subject><subject>Congenital defects</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Gestation</subject><subject>Gestational Age</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infants (Premature)</subject><subject>Intensive care</subject><subject>Intensive care units</subject><subject>Intensive Care Units, Neonatal</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methods</subject><subject>Morbidity</subject><subject>Neonatal care</subject><subject>Neonatal intensive care</subject><subject>Neonates</subject><subject>Patient outcomes</subject><subject>Pediatric research</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Population studies</subject><subject>Pregnancy</subject><subject>Retrospective 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Newborn</topic><topic>Infants</topic><topic>Infants (Premature)</topic><topic>Intensive care</topic><topic>Intensive care units</topic><topic>Intensive Care Units, Neonatal</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methods</topic><topic>Morbidity</topic><topic>Neonatal care</topic><topic>Neonatal intensive care</topic><topic>Neonates</topic><topic>Patient outcomes</topic><topic>Pediatric research</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Population studies</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puia-Dumitrescu, Mihai</creatorcontrib><creatorcontrib>Younge, Noelle</creatorcontrib><creatorcontrib>Benjamin, Daniel K.</creatorcontrib><creatorcontrib>Lawson, Katie</creatorcontrib><creatorcontrib>Hume, Cordelia</creatorcontrib><creatorcontrib>Hill, 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perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>40</volume><issue>5</issue><spage>781</spage><epage>789</epage><pages>781-789</pages><issn>0743-8346</issn><issn>1476-5543</issn><eissn>1476-5543</eissn><abstract>Objective
To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22–24 weeks of gestation.
Study design
Multicenter retrospective cohort study of infants born 22–24 weeks of gestation (2006–2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group.
Results
This study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016).
Conclusions
A large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>32066843</pmid><doi>10.1038/s41372-020-0614-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7847-5204</orcidid><orcidid>https://orcid.org/0000-0003-4156-8543</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2020-05, Vol.40 (5), p.781-789 |
| issn | 0743-8346 1476-5543 1476-5543 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7293630 |
| source | MEDLINE; SpringerLink Journals |
| subjects | 692/308/409 692/700/1720 Antibiotics Antiinfectives and antibacterials Birth Weight Congenital anomalies Congenital defects Drug therapy Female Gestation Gestational Age Hospitals Humans Infant Infant, Newborn Infants Infants (Premature) Intensive care Intensive care units Intensive Care Units, Neonatal Medicine Medicine & Public Health Methods Morbidity Neonatal care Neonatal intensive care Neonates Patient outcomes Pediatric research Pediatric Surgery Pediatrics Population studies Pregnancy Retrospective Studies Survival |
| title | Medications and in-hospital outcomes in infants born at 22–24 weeks of gestation |
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