Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase

Promysalin is a small-molecule natural product that specifically inhibits growth of the Gram-negative pathogen ( ). This activity holds promise in the treatment of multidrug resistant infections found in immunocompromised patients with chronic illnesses, such as cystic fibrosis. In 2015, our lab com...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS infectious diseases 2020-06, Vol.6 (6), p.1372-1377
Hauptverfasser:	Post, Savannah J, Keohane, Colleen E, Rossiter, Lauren M, Kaplan, Anna R, Khowsathit, Jittasak, Matuska, Katie, Karanicolas, John, Wuest, William M
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Pyrrolidines Salicylamides Succinate Dehydrogenase - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!