Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

The interplay between E2 and E3 enzymes regulates the polyubiquitination of substrates in eukaryotes. Among the several RING-domain E3 ligases in humans, many utilize two distinct E2s for polyubiquitination. For example, the cell cycle regulatory E3, human anaphase-promoting complex/cyclosome (APC/C...

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Veröffentlicht in:	Nature structural & molecular biology 2020-06, Vol.27 (6), p.550-560
Hauptverfasser:	Martinez-Chacin, Raquel C., Bodrug, Tatyana, Bolhuis, Derek L., Kedziora, Katarzyna M., Bonacci, Thomas, Ordureau, Alban, Gibbs, Morgan E., Weissmann, Florian, Qiao, Renping, Grant, Gavin D., Cook, Jeanette G., Peters, Jan-Michael, Wade Harper, J., Emanuele, Michael J., Brown, Nicholas G.
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Sprache:	eng
Schlagworte:	13/89 14/63 631/45 631/45/173 631/45/612 631/45/612/1223 631/45/612/645 82/29 82/58 82/80 82/83 Anaphase Anaphase-promoting complex Anaphase-Promoting Complex-Cyclosome - chemistry Anaphase-Promoting Complex-Cyclosome - genetics Anaphase-Promoting Complex-Cyclosome - metabolism Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism Biochemistry Biological Microscopy Biomedical and Life Sciences Cell cycle Chains Cytidine Triphosphate - metabolism Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Elongation Eukaryotes HeLa Cells Humans Life Sciences Membrane Biology Polyubiquitin - metabolism Priming Protein Structure Substrates Ubiquitin Ubiquitin - metabolism Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism Ubiquitination
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