Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels

Melanoma represents the most serious type of skin cancer. Although recent years have seen advances using targeted and immunotherapies, most patients remain at high risk for tumor recurrence. Here we show that IRAK-M, a negative regulator of MyD88 signaling, is deficient or low in melanoma and expres...

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Veröffentlicht in:	Communications biology 2020-06, Vol.3 (1), p.306-306, Article 306
Hauptverfasser:	Geng, Degui, Ciavattone, Nicholas, Lasola, Jackline Joy, Shrestha, Rojesh, Sanchez, Amelia, Guo, Jitao, Vlk, Alexandra, Younis, Rania, Wang, Lucy, Brown, Alex J., Zhang, Yuji, Velasco-Gonzalez, Cruz, Tan, Aik-Choon, Davila, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/2 13/31 13/44 13/51 13/89 14/63 45/29 45/61 45/90 631/67/1813/1634 631/80/82/23 64/60 692/4028/67/1813/1634 96/1 Animals Antitumor activity Apoptosis Biology Biomedical and Life Sciences Calcium-Binding Proteins - antagonists & inhibitors Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Calpain Calpastatin Caspase 3 - genetics Caspase 3 - metabolism Caspase-3 Caspase-8 Cell Proliferation Cytotoxicity Drug development Drug screening Female Gene Expression Regulation, Neoplastic Humans Immunotherapy Inflammation Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - metabolism Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Life Sciences Melanoma Melanoma - genetics Melanoma - metabolism Melanoma - pathology Mice Mice, Inbred NOD Mice, SCID MyD88 protein Skin cancer Survival Therapeutic applications TRAF6 protein Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays
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