Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presen...
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| Veröffentlicht in: | Nano letters 2020-06, Vol.20 (6), p.4472-4480 |
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| creator | Pijpers, Imke A B Cao, Shoupeng Llopis-Lorente, Antoni Zhu, Jianzhi Song, Shidong Joosten, Rick R M Meng, Fenghua Friedrich, Heiner Williams, David S Sánchez, Samuel van Hest, Jan C M Abdelmohsen, Loai K E A |
| description | Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presented. However, enzymes are highly susceptible to proteolysis and deactivation in biological milieu. Biodegradable hybrid nanomotors powered by catalytic inorganic nanoparticles provide a proteolytically stable alternative to those based upon enzymes. Herein we describe the assembly of hybrid biodegradable nanomotors capable of transducing chemical energy into motion. Such nanomotors are constructed through a process of compartmentalized synthesis of inorganic MnO
nanoparticles (MnPs) within the cavity of organic stomatocytes. We show that the nanomotors remain active in cellular environments and do not compromise cell viability. Effective tumor penetration of hybrid nanomotors is also demonstrated in proof-of-principle experiments. Overall, this work represents a new prospect for engineering of nanomotors that can retain their functionality within biological contexts. |
| doi_str_mv | 10.1021/acs.nanolett.0c01268 |
| format | Article |
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nanoparticles (MnPs) within the cavity of organic stomatocytes. We show that the nanomotors remain active in cellular environments and do not compromise cell viability. Effective tumor penetration of hybrid nanomotors is also demonstrated in proof-of-principle experiments. Overall, this work represents a new prospect for engineering of nanomotors that can retain their functionality within biological contexts.</description><identifier>ISSN: 1530-6984</identifier><identifier>EISSN: 1530-6992</identifier><identifier>DOI: 10.1021/acs.nanolett.0c01268</identifier><identifier>PMID: 32427492</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Letter</subject><ispartof>Nano letters, 2020-06, Vol.20 (6), p.4472-4480</ispartof><rights>Copyright © 2020 American Chemical Society 2020 American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-aef1ec32b5eaad0431ae5655c053e02cead273c20e20a0d7177dd973500429ac3</citedby><cites>FETCH-LOGICAL-c408t-aef1ec32b5eaad0431ae5655c053e02cead273c20e20a0d7177dd973500429ac3</cites><orcidid>0000-0003-4582-0064 ; 0000-0002-5845-8941 ; 0000-0001-7973-2404 ; 0000-0002-0094-1893 ; 0000-0002-8608-7738 ; 0000-0002-8209-6899</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2765,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32427492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pijpers, Imke A B</creatorcontrib><creatorcontrib>Cao, Shoupeng</creatorcontrib><creatorcontrib>Llopis-Lorente, Antoni</creatorcontrib><creatorcontrib>Zhu, Jianzhi</creatorcontrib><creatorcontrib>Song, Shidong</creatorcontrib><creatorcontrib>Joosten, Rick R M</creatorcontrib><creatorcontrib>Meng, Fenghua</creatorcontrib><creatorcontrib>Friedrich, Heiner</creatorcontrib><creatorcontrib>Williams, David S</creatorcontrib><creatorcontrib>Sánchez, Samuel</creatorcontrib><creatorcontrib>van Hest, Jan C M</creatorcontrib><creatorcontrib>Abdelmohsen, Loai K E A</creatorcontrib><title>Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis</title><title>Nano letters</title><addtitle>Nano Lett</addtitle><description>Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presented. However, enzymes are highly susceptible to proteolysis and deactivation in biological milieu. Biodegradable hybrid nanomotors powered by catalytic inorganic nanoparticles provide a proteolytically stable alternative to those based upon enzymes. Herein we describe the assembly of hybrid biodegradable nanomotors capable of transducing chemical energy into motion. Such nanomotors are constructed through a process of compartmentalized synthesis of inorganic MnO
nanoparticles (MnPs) within the cavity of organic stomatocytes. We show that the nanomotors remain active in cellular environments and do not compromise cell viability. Effective tumor penetration of hybrid nanomotors is also demonstrated in proof-of-principle experiments. 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| subjects | Letter |
| title | Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis |
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