Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic diso...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2020-05, Vol.9 (5), p.1417 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | 1417 |
| container_title | Journal of clinical medicine |
| container_volume | 9 |
| creator | Sardu, Celestino Gambardella, Jessica Morelli, Marco Bruno Wang, Xujun Marfella, Raffaele Santulli, Gaetano |
| description | The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations. |
| doi_str_mv | 10.3390/jcm9051417 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7290769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2641069266</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-81e6dc814f797fede529aee9d0e6a0192d2af20acfb9b1a26580b7062d57a3813</originalsourceid><addsrcrecordid>eNpdkctu1DAUhiMEolXphgdAltigakJ9ydgxC6qSTumISt0UtpZjnzAeJfZgJyPNg_C-9agXSr3xkc6nz-f4L4r3BH9mTOLTtRkknpOKiFfFIcVClJjV7PWz-qA4TmmN86nrihLxtjhgtMIsl4fF36vdBuIIPrngZ-h2FcPQhuTSDP1w1sMOXWrXTxFmSHuLLpxuYYT0BS0Tam5-LS9KInMHLbwN4wp6p_sMJdAJztA5asKwibDa67eAFlvdT3rML6HQoaZ33pnM78XfdHImA86CN_CueNPpPsHxw31U_Lxc3DZX5fXN92Vzfl2aStCxrAlwa2pSdUKKDizMqdQA0mLgGhNJLdUdxdp0rWyJpnxe41ZgTu1caFYTdlR8vfdupnYAa8CPUfdqE92g404F7dT_He9W6nfYKkElFlxmwacHQQx_JkijGlwy0PfaQ5iS2v8zZryqqox-fIGuwxR9Xk9RXhHMJeU8Uyf3lIkhpQjd0zAEq33g6l_gGf7wfPwn9DFedgdaa6Zw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2641069266</pqid></control><display><type>article</type><title>Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence</title><source>Open Access: PubMed Central</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Free E-Journal (出版社公開部分のみ）</source><creator>Sardu, Celestino ; Gambardella, Jessica ; Morelli, Marco Bruno ; Wang, Xujun ; Marfella, Raffaele ; Santulli, Gaetano</creator><creatorcontrib>Sardu, Celestino ; Gambardella, Jessica ; Morelli, Marco Bruno ; Wang, Xujun ; Marfella, Raffaele ; Santulli, Gaetano</creatorcontrib><description>The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9051417</identifier><identifier>PMID: 32403217</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anticoagulants ; Avian flu ; Blood pressure ; Clinical medicine ; Coronaviruses ; COVID-19 ; Diabetes ; Disease ; Endothelium ; Gene expression ; Glycoproteins ; Hospitals ; Hypertension ; Infections ; Morbidity ; Mortality ; Pathogenesis ; Proteins ; Review ; Severe acute respiratory syndrome coronavirus 2 ; Thrombosis ; Ventilators</subject><ispartof>Journal of clinical medicine, 2020-05, Vol.9 (5), p.1417</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-81e6dc814f797fede529aee9d0e6a0192d2af20acfb9b1a26580b7062d57a3813</citedby><cites>FETCH-LOGICAL-c472t-81e6dc814f797fede529aee9d0e6a0192d2af20acfb9b1a26580b7062d57a3813</cites><orcidid>0000-0001-7231-375X ; 0000-0001-5099-3790</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290769/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290769/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32403217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sardu, Celestino</creatorcontrib><creatorcontrib>Gambardella, Jessica</creatorcontrib><creatorcontrib>Morelli, Marco Bruno</creatorcontrib><creatorcontrib>Wang, Xujun</creatorcontrib><creatorcontrib>Marfella, Raffaele</creatorcontrib><creatorcontrib>Santulli, Gaetano</creatorcontrib><title>Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.</description><subject>Anticoagulants</subject><subject>Avian flu</subject><subject>Blood pressure</subject><subject>Clinical medicine</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Endothelium</subject><subject>Gene expression</subject><subject>Glycoproteins</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Pathogenesis</subject><subject>Proteins</subject><subject>Review</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Thrombosis</subject><subject>Ventilators</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkctu1DAUhiMEolXphgdAltigakJ9ydgxC6qSTumISt0UtpZjnzAeJfZgJyPNg_C-9agXSr3xkc6nz-f4L4r3BH9mTOLTtRkknpOKiFfFIcVClJjV7PWz-qA4TmmN86nrihLxtjhgtMIsl4fF36vdBuIIPrngZ-h2FcPQhuTSDP1w1sMOXWrXTxFmSHuLLpxuYYT0BS0Tam5-LS9KInMHLbwN4wp6p_sMJdAJztA5asKwibDa67eAFlvdT3rML6HQoaZ33pnM78XfdHImA86CN_CueNPpPsHxw31U_Lxc3DZX5fXN92Vzfl2aStCxrAlwa2pSdUKKDizMqdQA0mLgGhNJLdUdxdp0rWyJpnxe41ZgTu1caFYTdlR8vfdupnYAa8CPUfdqE92g404F7dT_He9W6nfYKkElFlxmwacHQQx_JkijGlwy0PfaQ5iS2v8zZryqqox-fIGuwxR9Xk9RXhHMJeU8Uyf3lIkhpQjd0zAEq33g6l_gGf7wfPwn9DFedgdaa6Zw</recordid><startdate>20200511</startdate><enddate>20200511</enddate><creator>Sardu, Celestino</creator><creator>Gambardella, Jessica</creator><creator>Morelli, Marco Bruno</creator><creator>Wang, Xujun</creator><creator>Marfella, Raffaele</creator><creator>Santulli, Gaetano</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7231-375X</orcidid><orcidid>https://orcid.org/0000-0001-5099-3790</orcidid></search><sort><creationdate>20200511</creationdate><title>Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence</title><author>Sardu, Celestino ; Gambardella, Jessica ; Morelli, Marco Bruno ; Wang, Xujun ; Marfella, Raffaele ; Santulli, Gaetano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-81e6dc814f797fede529aee9d0e6a0192d2af20acfb9b1a26580b7062d57a3813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anticoagulants</topic><topic>Avian flu</topic><topic>Blood pressure</topic><topic>Clinical medicine</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Endothelium</topic><topic>Gene expression</topic><topic>Glycoproteins</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Infections</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Pathogenesis</topic><topic>Proteins</topic><topic>Review</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Thrombosis</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sardu, Celestino</creatorcontrib><creatorcontrib>Gambardella, Jessica</creatorcontrib><creatorcontrib>Morelli, Marco Bruno</creatorcontrib><creatorcontrib>Wang, Xujun</creatorcontrib><creatorcontrib>Marfella, Raffaele</creatorcontrib><creatorcontrib>Santulli, Gaetano</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sardu, Celestino</au><au>Gambardella, Jessica</au><au>Morelli, Marco Bruno</au><au>Wang, Xujun</au><au>Marfella, Raffaele</au><au>Santulli, Gaetano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2020-05-11</date><risdate>2020</risdate><volume>9</volume><issue>5</issue><spage>1417</spage><pages>1417-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32403217</pmid><doi>10.3390/jcm9051417</doi><orcidid>https://orcid.org/0000-0001-7231-375X</orcidid><orcidid>https://orcid.org/0000-0001-5099-3790</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2020-05, Vol.9 (5), p.1417 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7290769 |
| source | Open Access: PubMed Central; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; Free E-Journal (出版社公開部分のみ） |
| subjects | Anticoagulants Avian flu Blood pressure Clinical medicine Coronaviruses COVID-19 Diabetes Disease Endothelium Gene expression Glycoproteins Hospitals Hypertension Infections Morbidity Mortality Pathogenesis Proteins Review Severe acute respiratory syndrome coronavirus 2 Thrombosis Ventilators |
| title | Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A33%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hypertension,%20Thrombosis,%20Kidney%20Failure,%20and%20Diabetes:%20Is%20COVID-19%20an%20Endothelial%20Disease?%20A%20Comprehensive%20Evaluation%20of%20Clinical%20and%20Basic%20Evidence&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Sardu,%20Celestino&rft.date=2020-05-11&rft.volume=9&rft.issue=5&rft.spage=1417&rft.pages=1417-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm9051417&rft_dat=%3Cproquest_pubme%3E2641069266%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2641069266&rft_id=info:pmid/32403217&rfr_iscdi=true |