Sensory Nociceptive Neurons Contribute to Host Protection During Enteric Infection With Citrobacter rodentium

Abstract Background Neurons are an integral component of the immune system that functions to coordinate responses to bacterial pathogens. Sensory nociceptive neurons that can detect bacterial pathogens are found throughout the body with dense innervation of the intestinal tract. Methods In this stud...

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Veröffentlicht in:	The Journal of infectious diseases 2020-06, Vol.221 (12), p.1978-1988
Hauptverfasser:	Ramirez, Valerie T, Sladek, Jessica, Godinez, Dayn Romero, Rude, Kavi M, Chicco, Pamela, Murray, Kaitlin, Brust-Mascher, Ingrid, Gareau, Melanie G, Reardon, Colin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Calcitonin Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - metabolism Calcitonin Gene-Related Peptide Receptor Antagonists - pharmacology Citrobacter rodentium Citrobacter rodentium - immunology Disease Models, Animal Enteric Nervous System - cytology Enteric Nervous System - drug effects Enteric Nervous System - immunology Enterobacteriaceae Infections - immunology Enterobacteriaceae Infections - microbiology Gene expression Host-Pathogen Interactions - drug effects Host-Pathogen Interactions - immunology Humans Immune clearance Immune system Infections Inflammation Innervation Interleukin 22 Intestinal Mucosa - innervation Intestinal Mucosa - microbiology Intestine, Small - innervation Intestine, Small - microbiology Major and Brief Reports Mice Mice, Knockout Nerves Neurons Nociceptors - drug effects Nociceptors - immunology Nociceptors - metabolism Pain perception Pathogens Receptors, Calcitonin Gene-Related Peptide - metabolism Sensory neurons Small intestine TRPV Cation Channels - genetics
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