Insights from Drosophila on mitochondrial complex I
NADH:ubiquinone oxidoreductase, more commonly referred to as mitochondrial complex I (CI), is the largest discrete enzyme of the oxidative phosphorylation system (OXPHOS). It is localized to the mitochondrial inner membrane. CI oxidizes NADH generated from the tricarboxylic acid cycle to NAD + , in...
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creator | Rhooms, Shauna-Kay Murari, Anjaneyulu Goparaju, Naga Sri Vidya Vilanueva, Maximino Owusu-Ansah, Edward |
description | NADH:ubiquinone oxidoreductase, more commonly referred to as mitochondrial complex I (CI), is the largest discrete enzyme of the oxidative phosphorylation system (OXPHOS). It is localized to the mitochondrial inner membrane. CI oxidizes NADH generated from the tricarboxylic acid cycle to NAD
+
, in a series of redox reactions that culminates in the reduction of ubiquinone, and the transport of protons from the matrix across the inner membrane to the intermembrane space. The resulting proton-motive force is consumed by ATP synthase to generate ATP, or harnessed to transport ions, metabolites and proteins into the mitochondrion. CI is also a major source of reactive oxygen species. Accordingly, impaired CI function has been associated with a host of chronic metabolic and degenerative disorders such as diabetes, cardiomyopathy, Parkinson’s disease (PD) and Leigh syndrome. Studies on
Drosophila
have contributed to our understanding of the multiple roles of CI in bioenergetics and organismal physiology. Here, we explore and discuss some of the studies on
Drosophila
that have informed our understanding of this complex and conclude with some of the open questions about CI that can be resolved by studies on
Drosophila
. |
doi_str_mv | 10.1007/s00018-019-03293-0 |
format | Article |
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+
, in a series of redox reactions that culminates in the reduction of ubiquinone, and the transport of protons from the matrix across the inner membrane to the intermembrane space. The resulting proton-motive force is consumed by ATP synthase to generate ATP, or harnessed to transport ions, metabolites and proteins into the mitochondrion. CI is also a major source of reactive oxygen species. Accordingly, impaired CI function has been associated with a host of chronic metabolic and degenerative disorders such as diabetes, cardiomyopathy, Parkinson’s disease (PD) and Leigh syndrome. Studies on
Drosophila
have contributed to our understanding of the multiple roles of CI in bioenergetics and organismal physiology. Here, we explore and discuss some of the studies on
Drosophila
that have informed our understanding of this complex and conclude with some of the open questions about CI that can be resolved by studies on
Drosophila
.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-019-03293-0</identifier><identifier>PMID: 31485716</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; ATP ; ATP synthase ; Biochemistry ; Bioenergetics ; Biomedical and Life Sciences ; Biomedicine ; Cardiomyopathy ; Cell Biology ; Diabetes mellitus ; Drosophila ; Drosophila - metabolism ; Drosophila Proteins - metabolism ; Electron transport chain ; Electron Transport Complex I - metabolism ; Insects ; Life Sciences ; Metabolites ; Mitochondria ; Mitochondria - metabolism ; Movement disorders ; NAD ; NADH ; NADH-ubiquinone oxidoreductase ; Neurodegenerative diseases ; Nicotinamide adenine dinucleotide ; Oxidative Phosphorylation ; Parkinson's disease ; Phosphorylation ; Protein Subunits - metabolism ; Protonmotive force ; Protons ; Reactive oxygen species ; Redox reactions ; Review ; Transport ; Tricarboxylic acid cycle ; Ubiquinone ; Ubiquinone oxidoreductase</subject><ispartof>Cellular and molecular life sciences : CMLS, 2020-02, Vol.77 (4), p.607-618</ispartof><rights>Springer Nature Switzerland AG 2019</rights><rights>Cellular and Molecular Life Sciences is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-eec186d7a5971e76d8332facbac661dd0a0dfb407f8ae9a26a68760fd39763e03</citedby><cites>FETCH-LOGICAL-c474t-eec186d7a5971e76d8332facbac661dd0a0dfb407f8ae9a26a68760fd39763e03</cites><orcidid>0000-0002-3451-1752</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289077/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289077/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31485716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rhooms, Shauna-Kay</creatorcontrib><creatorcontrib>Murari, Anjaneyulu</creatorcontrib><creatorcontrib>Goparaju, Naga Sri Vidya</creatorcontrib><creatorcontrib>Vilanueva, Maximino</creatorcontrib><creatorcontrib>Owusu-Ansah, Edward</creatorcontrib><title>Insights from Drosophila on mitochondrial complex I</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>NADH:ubiquinone oxidoreductase, more commonly referred to as mitochondrial complex I (CI), is the largest discrete enzyme of the oxidative phosphorylation system (OXPHOS). It is localized to the mitochondrial inner membrane. CI oxidizes NADH generated from the tricarboxylic acid cycle to NAD
+
, in a series of redox reactions that culminates in the reduction of ubiquinone, and the transport of protons from the matrix across the inner membrane to the intermembrane space. The resulting proton-motive force is consumed by ATP synthase to generate ATP, or harnessed to transport ions, metabolites and proteins into the mitochondrion. CI is also a major source of reactive oxygen species. Accordingly, impaired CI function has been associated with a host of chronic metabolic and degenerative disorders such as diabetes, cardiomyopathy, Parkinson’s disease (PD) and Leigh syndrome. Studies on
Drosophila
have contributed to our understanding of the multiple roles of CI in bioenergetics and organismal physiology. Here, we explore and discuss some of the studies on
Drosophila
that have informed our understanding of this complex and conclude with some of the open questions about CI that can be resolved by studies on
Drosophila
.</description><subject>Animals</subject><subject>ATP</subject><subject>ATP synthase</subject><subject>Biochemistry</subject><subject>Bioenergetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiomyopathy</subject><subject>Cell Biology</subject><subject>Diabetes mellitus</subject><subject>Drosophila</subject><subject>Drosophila - metabolism</subject><subject>Drosophila Proteins - metabolism</subject><subject>Electron transport chain</subject><subject>Electron Transport Complex I - metabolism</subject><subject>Insects</subject><subject>Life Sciences</subject><subject>Metabolites</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Movement disorders</subject><subject>NAD</subject><subject>NADH</subject><subject>NADH-ubiquinone oxidoreductase</subject><subject>Neurodegenerative diseases</subject><subject>Nicotinamide adenine dinucleotide</subject><subject>Oxidative Phosphorylation</subject><subject>Parkinson's disease</subject><subject>Phosphorylation</subject><subject>Protein Subunits - metabolism</subject><subject>Protonmotive force</subject><subject>Protons</subject><subject>Reactive oxygen species</subject><subject>Redox reactions</subject><subject>Review</subject><subject>Transport</subject><subject>Tricarboxylic acid cycle</subject><subject>Ubiquinone</subject><subject>Ubiquinone oxidoreductase</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kctOwzAQRS0EoqXwAyxQJDZsAmM7sZ0NEiqvSpXYgMTOch2nSZXEwU4R_D0uLeWxYDWW5vjO3LkIHWM4xwD8wgMAFjHgLAZKMhrDDhrihECcAce7mzcT5HmADrxfBDoVhO2jAcWJSDlmQ0Qnra_mZe-jwtkmunbW266sahXZNmqq3urStrmrVB1p23S1eYsmh2ivULU3R5s6Qk-3N4_j-3j6cDcZX01jnfCkj43RWLCcqzTj2HCWC0pJofRMacZwnoOCvJglwAuhTKYIU0xwBkVOM86oATpCl2vdbjlrTK5N2ztVy85VjXLv0qpK_u60VSnn9lVyIsIFeBA42wg4-7I0vpdN5bWpa9Uau_SSEJFiTBhLA3r6B13YpWuDvRWVkIwnmAWKrCkd7uSdKbbLYJCrTOQ6ExkykZ-ZyJWNk582tl--QggAXQM-tNq5cd-z_5H9AIwCl2U</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Rhooms, Shauna-Kay</creator><creator>Murari, Anjaneyulu</creator><creator>Goparaju, Naga Sri Vidya</creator><creator>Vilanueva, Maximino</creator><creator>Owusu-Ansah, Edward</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3451-1752</orcidid></search><sort><creationdate>20200201</creationdate><title>Insights from Drosophila on mitochondrial complex I</title><author>Rhooms, Shauna-Kay ; Murari, Anjaneyulu ; Goparaju, Naga Sri Vidya ; Vilanueva, Maximino ; Owusu-Ansah, Edward</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-eec186d7a5971e76d8332facbac661dd0a0dfb407f8ae9a26a68760fd39763e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>ATP</topic><topic>ATP synthase</topic><topic>Biochemistry</topic><topic>Bioenergetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiomyopathy</topic><topic>Cell Biology</topic><topic>Diabetes mellitus</topic><topic>Drosophila</topic><topic>Drosophila - metabolism</topic><topic>Drosophila Proteins - metabolism</topic><topic>Electron transport chain</topic><topic>Electron Transport Complex I - metabolism</topic><topic>Insects</topic><topic>Life Sciences</topic><topic>Metabolites</topic><topic>Mitochondria</topic><topic>Mitochondria - metabolism</topic><topic>Movement disorders</topic><topic>NAD</topic><topic>NADH</topic><topic>NADH-ubiquinone oxidoreductase</topic><topic>Neurodegenerative diseases</topic><topic>Nicotinamide adenine dinucleotide</topic><topic>Oxidative Phosphorylation</topic><topic>Parkinson's disease</topic><topic>Phosphorylation</topic><topic>Protein Subunits - metabolism</topic><topic>Protonmotive force</topic><topic>Protons</topic><topic>Reactive oxygen species</topic><topic>Redox reactions</topic><topic>Review</topic><topic>Transport</topic><topic>Tricarboxylic acid cycle</topic><topic>Ubiquinone</topic><topic>Ubiquinone oxidoreductase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rhooms, Shauna-Kay</creatorcontrib><creatorcontrib>Murari, Anjaneyulu</creatorcontrib><creatorcontrib>Goparaju, Naga Sri Vidya</creatorcontrib><creatorcontrib>Vilanueva, Maximino</creatorcontrib><creatorcontrib>Owusu-Ansah, Edward</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rhooms, Shauna-Kay</au><au>Murari, Anjaneyulu</au><au>Goparaju, Naga Sri Vidya</au><au>Vilanueva, Maximino</au><au>Owusu-Ansah, Edward</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insights from Drosophila on mitochondrial complex I</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>77</volume><issue>4</issue><spage>607</spage><epage>618</epage><pages>607-618</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>NADH:ubiquinone oxidoreductase, more commonly referred to as mitochondrial complex I (CI), is the largest discrete enzyme of the oxidative phosphorylation system (OXPHOS). It is localized to the mitochondrial inner membrane. CI oxidizes NADH generated from the tricarboxylic acid cycle to NAD
+
, in a series of redox reactions that culminates in the reduction of ubiquinone, and the transport of protons from the matrix across the inner membrane to the intermembrane space. The resulting proton-motive force is consumed by ATP synthase to generate ATP, or harnessed to transport ions, metabolites and proteins into the mitochondrion. CI is also a major source of reactive oxygen species. Accordingly, impaired CI function has been associated with a host of chronic metabolic and degenerative disorders such as diabetes, cardiomyopathy, Parkinson’s disease (PD) and Leigh syndrome. Studies on
Drosophila
have contributed to our understanding of the multiple roles of CI in bioenergetics and organismal physiology. Here, we explore and discuss some of the studies on
Drosophila
that have informed our understanding of this complex and conclude with some of the open questions about CI that can be resolved by studies on
Drosophila
.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31485716</pmid><doi>10.1007/s00018-019-03293-0</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3451-1752</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animals ATP ATP synthase Biochemistry Bioenergetics Biomedical and Life Sciences Biomedicine Cardiomyopathy Cell Biology Diabetes mellitus Drosophila Drosophila - metabolism Drosophila Proteins - metabolism Electron transport chain Electron Transport Complex I - metabolism Insects Life Sciences Metabolites Mitochondria Mitochondria - metabolism Movement disorders NAD NADH NADH-ubiquinone oxidoreductase Neurodegenerative diseases Nicotinamide adenine dinucleotide Oxidative Phosphorylation Parkinson's disease Phosphorylation Protein Subunits - metabolism Protonmotive force Protons Reactive oxygen species Redox reactions Review Transport Tricarboxylic acid cycle Ubiquinone Ubiquinone oxidoreductase |
title | Insights from Drosophila on mitochondrial complex I |
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