Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells

Uveal melanoma (UM) is the most common primary intraocular tumour in adults. The most accurate prognostic factor of UM is classification by gene expression profiling. Currently, the role of epigenetics is much less defined compared to genetic mechanisms. We recently showed a strong prognostic role o...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2020-05, Vol.12 (10), p.9745-9760
Hauptverfasser:	Giallongo, Sebastiano, Di Rosa, Michelino, Caltabiano, Rosario, Longhitano, Lucia, Reibaldi, Michele, Distefano, Alfio, Lo Re, Oriana, Amorini, Angela Maria, Puzzo, Lidia, Salvatorelli, Lucia, Palmucci, Stefano, Tibullo, Daniele, Russo, Andrea, Longo, Antonio, Lazzarino, Giacomo, Li Volti, Giovanni, Vinciguerra, Manlio
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Proliferation - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Neoplastic - genetics Histones - deficiency Humans Melanocytes - metabolism Melanoma - genetics Mitochondria - metabolism Mitochondrial Proteins - metabolism Neoplastic Stem Cells - metabolism Research Paper Transcription Factors - metabolism Uveal Neoplasms - genetics
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