Attenuation of doxorubicin-induced cardiotoxicity by cryptotanshinone detected through association analysis of transcriptomic profiling and KEGG pathway

The cardiotoxicity of doxorubicin (DOX) reduces the quality of life and prognosis of cancer patients, and therefore its clinical application has been largely restricted. This study aimed to assess the effects of cryptotanshione (CPT) on DOX-induced rat cardiac insufficiency. CPT treatment significan...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2020-05, Vol.12 (10), p.9585-9603
Hauptverfasser:	Li, Le, Wu, Bin, Zhao, Qiangqiang, Li, Jian, Han, Yunfeng, Fan, Xiaohang, Dong, Junli, Li, Pengcheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cardiotonic Agents - pharmacology Cardiotoxicity - drug therapy Cardiotoxicity - genetics Computational Biology Databases, Genetic Disease Models, Animal Doxorubicin Gene Expression Profiling Heart - drug effects Heart Diseases - chemically induced Heart Diseases - drug therapy Heart Diseases - genetics Metabolic Networks and Pathways - genetics Myocytes, Cardiac - drug effects Phenanthrenes - pharmacology Rats Reactive Oxygen Species - metabolism Research Paper Signal Transduction - drug effects Transcriptome - genetics
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