Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer

Cancer is driven by incremental changes that accumulate, eventually leading to oncogenic transformation. Although genetic alterations dominate the way cancer biologists think about oncogenesis, growing evidence suggests that systemic factors (for example, insulin, oestrogen and inflammatory cytokine...

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Veröffentlicht in:	Nature reviews. Endocrinology 2020-05, Vol.16 (5), p.276-283
Hauptverfasser:	Hopkins, Benjamin D., Goncalves, Marcus D., Cantley, Lewis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 631/45/275 631/67/1059/153 631/80/86/2369 692/4028/67/2195 Animals Biological Evolution Cancer Cellular signal transduction Cytokines Development and progression Endocrine system Endocrine System - metabolism Endocrinology Estrogens Genetic aspects Genetic transformation Health aspects Humans Inflammation Insulin Insulin - metabolism Kinases Lipid kinase Medicine Medicine & Public Health Metabolism Metabolites Molecular evolution Neoplasms - metabolism Nutrient status Oncology, Experimental Phenotypes Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Review Article Signal Transduction TOR protein Transcription Transferases Tumorigenesis Tumors
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