Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain
To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards. The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. e...
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| Veröffentlicht in: | Gene 2019-02, Vol.721, p.100005-100005, Article 100005 |
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| creator | Segura, Ana Ballester, Pura Ajo, Raquel Inda, María-del-Mar Urbano, Antonio Muriel, Javier Ochando, Isabel Margarit, César Martinez, Emi Peiró, Ana M. |
| description | To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.
The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.
A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.
T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.
•Sexuality on patients chronically treated with opioids is scarcely studied.•Prescribing opioids for chronic noncancer pain is highly associated to sexual adverse events, however, few of them are correctly diagnosed and treated.•Sexual comorbidity improved significantly after 6 months of andrological treatment, even more in patients carrying T786C-CC genotype.•Our results support that T786C polymorphism of eNOS gene is associated with a different ED response in CNP Spaniards males. |
| doi_str_mv | 10.1016/j.gene.2019.100005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7285905</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2590158319300026</els_id><sourcerecordid>2574408401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4035-8f96805fa198d5f8c0e889c9ced1b7f559f5e97b89558d6b41fc4e034b29d1a83</originalsourceid><addsrcrecordid>eNqFkcFvFCEUxonR2G31H_BgOHqZFRjYgcSYmKZakyZe9GgIA48OmxkYYbbp_vcybm30olwg8Hsf730fQq8o2VJCd2_321uIsGWEqnpRl3iCNlR2qiGklU_RhrSdbCil6gydl7L_hQj2HJ21TAgiONug71fRpWWAMZgRx7DkYHG6Dw5wOcZlMAXw-gme03icUp6HUKaCTXQYMtgljIDdsfhDrOcUcYjYDjnFqjKbEF-gZ96MBV4-7Bfo28err5fXzc2XT58vP9w0lpNWNNKrnSTCG6qkE15aAlIqqyw42ndeCOUFqK6XSgjpdj2n3nIgLe-ZctTI9gK9P-nOh34CZyEu2Yx6zmEy-aiTCfrvlxgGfZvudMekUERUgTcPAjn9OEBZ9BSKhXE0EdKhaCY6zonkhP4f5ZR3bUt3rKLshNqcSsngHzuiRK8R6r1e3dVrhPoUYS16_ecsjyW_M6vAuxMA1dG7AFkXGyBWs8IaiXYp_Ev_J1Qort0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2414733162</pqid></control><display><type>article</type><title>Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain</title><source>PubMed Central Open Access</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Segura, Ana ; Ballester, Pura ; Ajo, Raquel ; Inda, María-del-Mar ; Urbano, Antonio ; Muriel, Javier ; Ochando, Isabel ; Margarit, César ; Martinez, Emi ; Peiró, Ana M.</creator><creatorcontrib>Segura, Ana ; Ballester, Pura ; Ajo, Raquel ; Inda, María-del-Mar ; Urbano, Antonio ; Muriel, Javier ; Ochando, Isabel ; Margarit, César ; Martinez, Emi ; Peiró, Ana M.</creatorcontrib><description>To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.
The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.
A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.
T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.
•Sexuality on patients chronically treated with opioids is scarcely studied.•Prescribing opioids for chronic noncancer pain is highly associated to sexual adverse events, however, few of them are correctly diagnosed and treated.•Sexual comorbidity improved significantly after 6 months of andrological treatment, even more in patients carrying T786C-CC genotype.•Our results support that T786C polymorphism of eNOS gene is associated with a different ED response in CNP Spaniards males.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>EISSN: 2590-1583</identifier><identifier>DOI: 10.1016/j.gene.2019.100005</identifier><identifier>PMID: 32550542</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Chronic pain ; eNOS gene ; Erectile dysfunction ; iPDE5 ; Pharmacogenetics ; T786C</subject><ispartof>Gene, 2019-02, Vol.721, p.100005-100005, Article 100005</ispartof><rights>2019</rights><rights>2019 Published by Elsevier B.V.</rights><rights>2019 Published by Elsevier B.V. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4035-8f96805fa198d5f8c0e889c9ced1b7f559f5e97b89558d6b41fc4e034b29d1a83</citedby><cites>FETCH-LOGICAL-c4035-8f96805fa198d5f8c0e889c9ced1b7f559f5e97b89558d6b41fc4e034b29d1a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285905/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gene.2019.100005$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3550,27924,27925,45995,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32550542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Segura, Ana</creatorcontrib><creatorcontrib>Ballester, Pura</creatorcontrib><creatorcontrib>Ajo, Raquel</creatorcontrib><creatorcontrib>Inda, María-del-Mar</creatorcontrib><creatorcontrib>Urbano, Antonio</creatorcontrib><creatorcontrib>Muriel, Javier</creatorcontrib><creatorcontrib>Ochando, Isabel</creatorcontrib><creatorcontrib>Margarit, César</creatorcontrib><creatorcontrib>Martinez, Emi</creatorcontrib><creatorcontrib>Peiró, Ana M.</creatorcontrib><title>Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain</title><title>Gene</title><addtitle>Gene X</addtitle><description>To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.
The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.
A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.
T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.
•Sexuality on patients chronically treated with opioids is scarcely studied.•Prescribing opioids for chronic noncancer pain is highly associated to sexual adverse events, however, few of them are correctly diagnosed and treated.•Sexual comorbidity improved significantly after 6 months of andrological treatment, even more in patients carrying T786C-CC genotype.•Our results support that T786C polymorphism of eNOS gene is associated with a different ED response in CNP Spaniards males.</description><subject>Chronic pain</subject><subject>eNOS gene</subject><subject>Erectile dysfunction</subject><subject>iPDE5</subject><subject>Pharmacogenetics</subject><subject>T786C</subject><issn>0378-1119</issn><issn>1879-0038</issn><issn>2590-1583</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkcFvFCEUxonR2G31H_BgOHqZFRjYgcSYmKZakyZe9GgIA48OmxkYYbbp_vcybm30olwg8Hsf730fQq8o2VJCd2_321uIsGWEqnpRl3iCNlR2qiGklU_RhrSdbCil6gydl7L_hQj2HJ21TAgiONug71fRpWWAMZgRx7DkYHG6Dw5wOcZlMAXw-gme03icUp6HUKaCTXQYMtgljIDdsfhDrOcUcYjYDjnFqjKbEF-gZ96MBV4-7Bfo28err5fXzc2XT58vP9w0lpNWNNKrnSTCG6qkE15aAlIqqyw42ndeCOUFqK6XSgjpdj2n3nIgLe-ZctTI9gK9P-nOh34CZyEu2Yx6zmEy-aiTCfrvlxgGfZvudMekUERUgTcPAjn9OEBZ9BSKhXE0EdKhaCY6zonkhP4f5ZR3bUt3rKLshNqcSsngHzuiRK8R6r1e3dVrhPoUYS16_ecsjyW_M6vAuxMA1dG7AFkXGyBWs8IaiXYp_Ev_J1Qort0</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Segura, Ana</creator><creator>Ballester, Pura</creator><creator>Ajo, Raquel</creator><creator>Inda, María-del-Mar</creator><creator>Urbano, Antonio</creator><creator>Muriel, Javier</creator><creator>Ochando, Isabel</creator><creator>Margarit, César</creator><creator>Martinez, Emi</creator><creator>Peiró, Ana M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190201</creationdate><title>Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain</title><author>Segura, Ana ; Ballester, Pura ; Ajo, Raquel ; Inda, María-del-Mar ; Urbano, Antonio ; Muriel, Javier ; Ochando, Isabel ; Margarit, César ; Martinez, Emi ; Peiró, Ana M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4035-8f96805fa198d5f8c0e889c9ced1b7f559f5e97b89558d6b41fc4e034b29d1a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chronic pain</topic><topic>eNOS gene</topic><topic>Erectile dysfunction</topic><topic>iPDE5</topic><topic>Pharmacogenetics</topic><topic>T786C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Segura, Ana</creatorcontrib><creatorcontrib>Ballester, Pura</creatorcontrib><creatorcontrib>Ajo, Raquel</creatorcontrib><creatorcontrib>Inda, María-del-Mar</creatorcontrib><creatorcontrib>Urbano, Antonio</creatorcontrib><creatorcontrib>Muriel, Javier</creatorcontrib><creatorcontrib>Ochando, Isabel</creatorcontrib><creatorcontrib>Margarit, César</creatorcontrib><creatorcontrib>Martinez, Emi</creatorcontrib><creatorcontrib>Peiró, Ana M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Segura, Ana</au><au>Ballester, Pura</au><au>Ajo, Raquel</au><au>Inda, María-del-Mar</au><au>Urbano, Antonio</au><au>Muriel, Javier</au><au>Ochando, Isabel</au><au>Margarit, César</au><au>Martinez, Emi</au><au>Peiró, Ana M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain</atitle><jtitle>Gene</jtitle><addtitle>Gene X</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>721</volume><spage>100005</spage><epage>100005</epage><pages>100005-100005</pages><artnum>100005</artnum><issn>0378-1119</issn><eissn>1879-0038</eissn><eissn>2590-1583</eissn><abstract>To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.
The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.
A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.
T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.
•Sexuality on patients chronically treated with opioids is scarcely studied.•Prescribing opioids for chronic noncancer pain is highly associated to sexual adverse events, however, few of them are correctly diagnosed and treated.•Sexual comorbidity improved significantly after 6 months of andrological treatment, even more in patients carrying T786C-CC genotype.•Our results support that T786C polymorphism of eNOS gene is associated with a different ED response in CNP Spaniards males.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32550542</pmid><doi>10.1016/j.gene.2019.100005</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Chronic pain eNOS gene Erectile dysfunction iPDE5 Pharmacogenetics T786C |
| title | Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain |
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