Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing

OBJECTIVE:Macrophages have been described in calcific aortic valve disease, but it is unclear if they promote or counteract calcification. We aimed to determine how macrophages are involved in calcification using the Notch1 model of calcific aortic valve disease. APPROACH AND RESULTS:Macrophages in...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2020-06, Vol.40 (6), p.e153-e165
Hauptverfasser:	Raddatz, Michael A., Huffstater, Tessa, Bersi, Matthew R., Reinfeld, Bradley I., Madden, Matthew Z., Booton, Sabrina E., Rathmell, W. Kimryn, Rathmell, Jeffrey C., Lindman, Brian R., Madhur, Meena S., Merryman, W. David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Valve - immunology Aortic Valve - pathology Aortic Valve - physiopathology Aortic Valve Stenosis - immunology Aortic Valve Stenosis - pathology Aortic Valve Stenosis - physiopathology Bone Marrow Transplantation Calcinosis - immunology Calcinosis - pathology Calcinosis - physiopathology Cell Movement Cyclic S-Oxides - pharmacology Disease Models, Animal Gene Expression Genotype Humans Inflammation - pathology Macrophages - chemistry Macrophages - pathology Macrophages - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Osteogenesis Receptor, Notch1 - analysis Receptor, Notch1 - genetics Receptor, Notch1 - physiology STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - physiology
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