Open vs. laparoscopic surgery for locally advanced gastric cancer after neoadjuvant therapy: Short-term and long-term survival outcomes
The aim of the present study was to compare the short-term and long-term survival outcomes of laparoscopic gastrectomy vs. open gastrectomy in treating locally advanced gastric cancer (LAGC) after neoadjuvant therapy. This study retrospectively reviewed the medical records of 270 patients with LAGC,...
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| Veröffentlicht in: | Oncology letters 2020-07, Vol.20 (1), p.861-867 |
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| creator | Wang, Nianchang Zhou, Aiping Jin, Jing Huang, Huang Zhang, Yawei Chen, Yingtai Zhao, Dongbing |
| description | The aim of the present study was to compare the short-term and long-term survival outcomes of laparoscopic gastrectomy vs. open gastrectomy in treating locally advanced gastric cancer (LAGC) after neoadjuvant therapy. This study retrospectively reviewed the medical records of 270 patients with LAGC, who underwent laparoscopic (n=49) or conventional open (n=221) surgery following neoadjuvant therapy between January 2007 and December 2016 in China National Cancer Center. Postoperative parameters and survival outcomes including overall survival and disease-free survival were analyzed. Patients who underwent laparoscopic gastrectomy (LP) had significantly shorter postoperative stay and a decreased number of metastatic lymph nodes harvested compared to those who underwent open surgery. The 75% disease-free survival (DFS) time in the laparoscopic surgery group (25.7 months) was higher compared with the open surgery group (15.6 months). However, no significant difference was observed in 5-year overall survival and DFS between the two groups. In conclusion, LG provides non-inferior short- and long-term survival outcomes compared with open surgery, suggesting a laparoscopic approach may be justified for patients with LAGC receiving neoadjuvant therapy. More randomized controlled trials are required to investigate the positive effects of LG for LAGC following neoadjuvant therapy. |
| doi_str_mv | 10.3892/ol.2020.11626 |
| format | Article |
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This study retrospectively reviewed the medical records of 270 patients with LAGC, who underwent laparoscopic (n=49) or conventional open (n=221) surgery following neoadjuvant therapy between January 2007 and December 2016 in China National Cancer Center. Postoperative parameters and survival outcomes including overall survival and disease-free survival were analyzed. Patients who underwent laparoscopic gastrectomy (LP) had significantly shorter postoperative stay and a decreased number of metastatic lymph nodes harvested compared to those who underwent open surgery. The 75% disease-free survival (DFS) time in the laparoscopic surgery group (25.7 months) was higher compared with the open surgery group (15.6 months). However, no significant difference was observed in 5-year overall survival and DFS between the two groups. In conclusion, LG provides non-inferior short- and long-term survival outcomes compared with open surgery, suggesting a laparoscopic approach may be justified for patients with LAGC receiving neoadjuvant therapy. More randomized controlled trials are required to investigate the positive effects of LG for LAGC following neoadjuvant therapy.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2020.11626</identifier><identifier>PMID: 32566013</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Adjuvant chemotherapy ; Analysis ; Cancer ; Cancer metastasis ; Cancer research ; Cancer therapies ; Cardiovascular disease ; Care and treatment ; Chemotherapy ; Gastric cancer ; Health aspects ; Laparoscopy ; Lymphatic system ; Medical records ; Metastasis ; Mortality ; Neoadjuvant therapy ; Oncology ; Patients ; Stomach cancer ; Surgery ; Tumors ; Variables</subject><ispartof>Oncology letters, 2020-07, Vol.20 (1), p.861-867</ispartof><rights>Copyright: © Wang et al.</rights><rights>COPYRIGHT 2020 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2020</rights><rights>Copyright: © Wang et al. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-c02a2846d7156ee5bb8ede4976d816ce1ebf0c5726667d470ea18e06d987223b3</citedby><cites>FETCH-LOGICAL-c513t-c02a2846d7156ee5bb8ede4976d816ce1ebf0c5726667d470ea18e06d987223b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285756/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285756/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32566013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Nianchang</creatorcontrib><creatorcontrib>Zhou, Aiping</creatorcontrib><creatorcontrib>Jin, Jing</creatorcontrib><creatorcontrib>Huang, Huang</creatorcontrib><creatorcontrib>Zhang, Yawei</creatorcontrib><creatorcontrib>Chen, Yingtai</creatorcontrib><creatorcontrib>Zhao, Dongbing</creatorcontrib><title>Open vs. laparoscopic surgery for locally advanced gastric cancer after neoadjuvant therapy: Short-term and long-term survival outcomes</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>The aim of the present study was to compare the short-term and long-term survival outcomes of laparoscopic gastrectomy vs. open gastrectomy in treating locally advanced gastric cancer (LAGC) after neoadjuvant therapy. This study retrospectively reviewed the medical records of 270 patients with LAGC, who underwent laparoscopic (n=49) or conventional open (n=221) surgery following neoadjuvant therapy between January 2007 and December 2016 in China National Cancer Center. Postoperative parameters and survival outcomes including overall survival and disease-free survival were analyzed. Patients who underwent laparoscopic gastrectomy (LP) had significantly shorter postoperative stay and a decreased number of metastatic lymph nodes harvested compared to those who underwent open surgery. The 75% disease-free survival (DFS) time in the laparoscopic surgery group (25.7 months) was higher compared with the open surgery group (15.6 months). However, no significant difference was observed in 5-year overall survival and DFS between the two groups. In conclusion, LG provides non-inferior short- and long-term survival outcomes compared with open surgery, suggesting a laparoscopic approach may be justified for patients with LAGC receiving neoadjuvant therapy. More randomized controlled trials are required to investigate the positive effects of LG for LAGC following neoadjuvant therapy.</description><subject>Adjuvant chemotherapy</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Cancer metastasis</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Gastric cancer</subject><subject>Health aspects</subject><subject>Laparoscopy</subject><subject>Lymphatic system</subject><subject>Medical records</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>Neoadjuvant therapy</subject><subject>Oncology</subject><subject>Patients</subject><subject>Stomach cancer</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Variables</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptklFvFCEQxzdGY5vaR18NiYnxZU9gd4H1waRpbDVp0gf1mXAwu7cXFlZgL7lP0K8t69WzZ4QEGOY3f2CYonhN8KoSLf3g7YpiileEMMqeFeeEt7QkWNDnxzWvz4rLGLc4t4YRIdjL4qyiDWOYVOfFw_0EDu3iClk1qeCj9tOgUZxDD2GPOh-Q9VpZu0fK7JTTYFCvYgoZ0osZkOpSHh14ZbZzRhJKGwhq2n9E3zY-pDK7R6ScyUquP1hZfzfslEV-TtqPEF8VLzplI1w-zhfFj5vP36-_lHf3t1-vr-5K3ZAqlRpTRUXNDCcNA2jWawEG6pYzIwjTQGDdYd1wyhjjpuYYFBGAmWkFp7RaVxfFp4PuNK9HMBpcCsrKKQyjCnvp1SBPPW7YyN7vJKei4Q3LAu8fBYL_OUNMchyiBmtVzsAcJa1JI_IVKcno23_QrZ-Dy89bKIZb2jL-l-qVBTm4zudz9SIqr1hFBcetWLRW_6FyNzAO2jvohrx_EvDuScAGlE2b6O2cBu_iKVgeQJ1_PwbojskgWC5VJr2VS5XJ31WW-TdPM3ik_9RU9QtbTs24</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Wang, Nianchang</creator><creator>Zhou, Aiping</creator><creator>Jin, Jing</creator><creator>Huang, Huang</creator><creator>Zhang, Yawei</creator><creator>Chen, Yingtai</creator><creator>Zhao, Dongbing</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200701</creationdate><title>Open vs. laparoscopic surgery for locally advanced gastric cancer after neoadjuvant therapy: Short-term and long-term survival outcomes</title><author>Wang, Nianchang ; Zhou, Aiping ; Jin, Jing ; Huang, Huang ; Zhang, Yawei ; Chen, Yingtai ; Zhao, Dongbing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-c02a2846d7156ee5bb8ede4976d816ce1ebf0c5726667d470ea18e06d987223b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adjuvant chemotherapy</topic><topic>Analysis</topic><topic>Cancer</topic><topic>Cancer metastasis</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Gastric cancer</topic><topic>Health aspects</topic><topic>Laparoscopy</topic><topic>Lymphatic system</topic><topic>Medical records</topic><topic>Metastasis</topic><topic>Mortality</topic><topic>Neoadjuvant therapy</topic><topic>Oncology</topic><topic>Patients</topic><topic>Stomach cancer</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Variables</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Nianchang</creatorcontrib><creatorcontrib>Zhou, Aiping</creatorcontrib><creatorcontrib>Jin, Jing</creatorcontrib><creatorcontrib>Huang, Huang</creatorcontrib><creatorcontrib>Zhang, Yawei</creatorcontrib><creatorcontrib>Chen, Yingtai</creatorcontrib><creatorcontrib>Zhao, Dongbing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Nianchang</au><au>Zhou, Aiping</au><au>Jin, Jing</au><au>Huang, Huang</au><au>Zhang, Yawei</au><au>Chen, Yingtai</au><au>Zhao, Dongbing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Open vs. laparoscopic surgery for locally advanced gastric cancer after neoadjuvant therapy: Short-term and long-term survival outcomes</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>20</volume><issue>1</issue><spage>861</spage><epage>867</epage><pages>861-867</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>The aim of the present study was to compare the short-term and long-term survival outcomes of laparoscopic gastrectomy vs. open gastrectomy in treating locally advanced gastric cancer (LAGC) after neoadjuvant therapy. This study retrospectively reviewed the medical records of 270 patients with LAGC, who underwent laparoscopic (n=49) or conventional open (n=221) surgery following neoadjuvant therapy between January 2007 and December 2016 in China National Cancer Center. Postoperative parameters and survival outcomes including overall survival and disease-free survival were analyzed. Patients who underwent laparoscopic gastrectomy (LP) had significantly shorter postoperative stay and a decreased number of metastatic lymph nodes harvested compared to those who underwent open surgery. The 75% disease-free survival (DFS) time in the laparoscopic surgery group (25.7 months) was higher compared with the open surgery group (15.6 months). However, no significant difference was observed in 5-year overall survival and DFS between the two groups. In conclusion, LG provides non-inferior short- and long-term survival outcomes compared with open surgery, suggesting a laparoscopic approach may be justified for patients with LAGC receiving neoadjuvant therapy. More randomized controlled trials are required to investigate the positive effects of LG for LAGC following neoadjuvant therapy.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>32566013</pmid><doi>10.3892/ol.2020.11626</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oncology letters, 2020-07, Vol.20 (1), p.861-867 |
| issn | 1792-1074 1792-1082 |
| language | eng |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adjuvant chemotherapy Analysis Cancer Cancer metastasis Cancer research Cancer therapies Cardiovascular disease Care and treatment Chemotherapy Gastric cancer Health aspects Laparoscopy Lymphatic system Medical records Metastasis Mortality Neoadjuvant therapy Oncology Patients Stomach cancer Surgery Tumors Variables |
| title | Open vs. laparoscopic surgery for locally advanced gastric cancer after neoadjuvant therapy: Short-term and long-term survival outcomes |
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