Immunomodulatory Effects of Vitamin D in Thyroid Diseases
Vitamin D is a secosteroid with a pleiotropic role in multiple physiological processes. Besides the well-known activity on bone homeostasis, recent studies suggested a peculiar role of vitamin D in different non-skeletal pathways, including a key role in the modulation of immune responses. Recent ev...
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| Veröffentlicht in: | Nutrients 2020-05, Vol.12 (5), p.1444 |
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| container_title | Nutrients |
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| creator | Mele, Chiara Caputo, Marina Bisceglia, Alessandro Samà, Maria Teresa Zavattaro, Marco Aimaretti, Gianluca Pagano, Loredana Prodam, Flavia Marzullo, Paolo |
| description | Vitamin D is a secosteroid with a pleiotropic role in multiple physiological processes. Besides the well-known activity on bone homeostasis, recent studies suggested a peculiar role of vitamin D in different non-skeletal pathways, including a key role in the modulation of immune responses. Recent evidences demonstrated that vitamin D acts on innate and adaptative immunity and seems to exert an immunomodulating action on autoimmune diseases and cancers. Several studies demonstrated a relationship between vitamin D deficiency, autoimmune thyroid disorders, and thyroid cancer. This review aims to summarize the evidences on the immunomodulatory effect of vitamin D on thyroid diseases. |
| doi_str_mv | 10.3390/nu12051444 |
| format | Article |
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Besides the well-known activity on bone homeostasis, recent studies suggested a peculiar role of vitamin D in different non-skeletal pathways, including a key role in the modulation of immune responses. Recent evidences demonstrated that vitamin D acts on innate and adaptative immunity and seems to exert an immunomodulating action on autoimmune diseases and cancers. Several studies demonstrated a relationship between vitamin D deficiency, autoimmune thyroid disorders, and thyroid cancer. This review aims to summarize the evidences on the immunomodulatory effect of vitamin D on thyroid diseases.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12051444</identifier><identifier>PMID: 32429416</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adaptive immunity ; Antigen presentation ; Antimicrobial agents ; Autoimmune diseases ; Biomarkers ; Bone turnover ; Calciferol ; Cytokines ; Enzymes ; Growth factors ; Homeostasis ; Humans ; Immune response ; Immune system ; Immunologic Factors - immunology ; Immunology ; Immunomodulation ; Immunomodulation - immunology ; Immunomodulators ; Infections ; Lymphocytes ; Medical research ; Pathogenesis ; Pathogens ; Physiology ; Review ; Thyroid cancer ; Thyroid diseases ; Thyroid Diseases - immunology ; Thyroiditis, Autoimmune - immunology ; Tumor necrosis factor-TNF ; Vitamin D ; Vitamin D - immunology ; Vitamin D Deficiency - immunology ; Vitamin deficiency</subject><ispartof>Nutrients, 2020-05, Vol.12 (5), p.1444</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adaptive immunity Antigen presentation Antimicrobial agents Autoimmune diseases Biomarkers Bone turnover Calciferol Cytokines Enzymes Growth factors Homeostasis Humans Immune response Immune system Immunologic Factors - immunology Immunology Immunomodulation Immunomodulation - immunology Immunomodulators Infections Lymphocytes Medical research Pathogenesis Pathogens Physiology Review Thyroid cancer Thyroid diseases Thyroid Diseases - immunology Thyroiditis, Autoimmune - immunology Tumor necrosis factor-TNF Vitamin D Vitamin D - immunology Vitamin D Deficiency - immunology Vitamin deficiency |
| title | Immunomodulatory Effects of Vitamin D in Thyroid Diseases |
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