Post-genomic progress in helminth parasitology
Helminth parasitology is an important discipline, which poses often unique technical challenges. One challenge is that helminth parasites, particularly those in humans, are often difficult to obtain alive and in sufficient quantities for study; another is the challenge of studying these organisms in...
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| Veröffentlicht in: | Parasitology 2020-07, Vol.147 (8), p.835-840 |
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| description | Helminth parasitology is an important discipline, which poses often unique technical challenges. One challenge is that helminth parasites, particularly those in humans, are often difficult to obtain alive and in sufficient quantities for study; another is the challenge of studying these organisms in vitro - no helminth parasite life cycle has been fully recapitulated outside of a host. Arguably, the key issue retarding progress in helminth parasitology has been a lack of experimental tools and resources, certainly relative to the riches that have driven many parasitologists to adopt free-living model organisms as surrogate systems. In response to these needs, the past 10-12 years have seen the beginnings of helminth parasitology's journey into the 'omics' era, with the release of abundant sequencing resources, and the functional genomics tools with which to test biological hypotheses. To reflect this progress, the 2019 Autumn Symposium of the British Society for Parasitology was held in Queen's University Belfast on the topic of 'post-genomic progress in helminth parasitology'. This issue presents examples of the current state of play in the field, while this editorial summarizes how genomic datasets and functional genomic tools have stimulated impressive recent progress in our understanding of parasite biology. |
| doi_str_mv | 10.1017/S0031182020000591 |
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| subjects | Animals Anthelmintics - therapeutic use Biology Consortia CRISPR CRISPR-Cas Systems Datasets Drug Resistance - genetics Enzymes Gene expression Genetics Genome, Helminth Genomes Genomics Helminthiasis - diagnosis Helminths - drug effects Helminths - genetics Helminths - metabolism Helminths - parasitology Humans Life cycles Nematodes Parasites Parasitology Parasitology - trends Pathology, Molecular Proteins Proteomics RNA Interference Transcriptome Tropical diseases Vaccines |
| title | Post-genomic progress in helminth parasitology |
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