Early risk factors of the exacerbation of coronavirus disease 2019 pneumonia
The purpose of this study was to investigate the early risk factors for the exacerbation of coronavirus disease 2019 (COVID‐19) pneumonia. Restrospective analysis of clinical data of 85 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), including gender, age, comorb...
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| Veröffentlicht in: | Journal of medical virology 2020-11, Vol.92 (11), p.2593-2599 |
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| creator | Wang, Chang‐Zheng Hu, Shun‐Lin Wang, Lin Li, Min Li, Huan‐Tian |
| description | The purpose of this study was to investigate the early risk factors for the exacerbation of coronavirus disease 2019 (COVID‐19) pneumonia. Restrospective analysis of clinical data of 85 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), including gender, age, comorbidities, symptoms, blood routine, clotting profile, biochemical examination, albumin, myocardial enzyme profile, inflammatory markers, and chest computed tomography (CT). All laboratory examinations were measured within first 24 hours after admission, and chest CT was performed before admission. A total of 56 (65.9%) patients had a history of exposure to the Huanan seafood market in Wuhan. Fever and dry cough accounted for the highest percentage of all symptoms. Male COVID‐2019 patients were more likely to develop severe pneumonia. Patients with severe and critical conditions are older and have higher rates of hypertension (P = .003) and coronary heart disease (P = .017). All severe and critical patients infected with SARS‐CoV‐2 showed bilateral lung involvement and have more multiple lobes involvement than common patients (P |
| doi_str_mv | 10.1002/jmv.26071 |
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Restrospective analysis of clinical data of 85 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), including gender, age, comorbidities, symptoms, blood routine, clotting profile, biochemical examination, albumin, myocardial enzyme profile, inflammatory markers, and chest computed tomography (CT). All laboratory examinations were measured within first 24 hours after admission, and chest CT was performed before admission. A total of 56 (65.9%) patients had a history of exposure to the Huanan seafood market in Wuhan. Fever and dry cough accounted for the highest percentage of all symptoms. Male COVID‐2019 patients were more likely to develop severe pneumonia. Patients with severe and critical conditions are older and have higher rates of hypertension (P = .003) and coronary heart disease (P = .017). All severe and critical patients infected with SARS‐CoV‐2 showed bilateral lung involvement and have more multiple lobes involvement than common patients (P < .001). Severe and critical patients showed higher white blood cell count (P = .006), neutrophil (NEU) count (P = .001), NEU% (P = .002), procalcitonin (P = .011), C‐reactive protein (P = .003), prothrombin time (P = .035), D‐dimer (P = .025), aspartate aminotransferase (P = .006), and lower lymphocyte (LYM) count (P = .019), LYM% (P = .001), albumin (P < .001). Logistic regression analysis showed that NEU count is an independent risk factor for deterioration, with the threshold of 6.5 × 109·L−1. We concluded that the laboratory independent risk factor for the progression of COVID‐19 pneumonia is NEU count. In addition, COVID‐19 patients with bilateral lung involvement or multiple lobes involvement should be taken seriously and actively treated to prevent deterioration of the disease.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.26071</identifier><identifier>PMID: 32470167</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Albumin ; Albumins ; Aspartate aminotransferase ; Blood ; Cardiovascular disease ; Cardiovascular diseases ; Chest ; chest CT ; China ; clinical features ; Clotting ; Comorbidity ; Computed tomography ; Coronary artery disease ; Coronaviridae ; Coronaviruses ; Cough ; COVID-19 ; COVID-19 - complications ; COVID-19 - diagnosis ; COVID-19 - physiopathology ; Dimers ; Disease Progression ; ErbB-2 protein ; Female ; Fever ; Heart diseases ; Hospitalization ; Humans ; Hypertension ; Inflammation ; Laboratories ; Leukocytes ; Lobes ; Lung - pathology ; Lung - virology ; Lungs ; Lymphocytes ; Male ; Middle Aged ; Pneumonia ; Procalcitonin ; Prothrombin ; Regression analysis ; Respiratory diseases ; Retrospective Studies ; Risk analysis ; Risk Factors ; SARS‐CoV‐2 ; Seafood ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Sex Factors ; Signs and symptoms ; Symptom Flare Up ; Tomography, X-Ray Computed ; Viral diseases ; Virology</subject><ispartof>Journal of medical virology, 2020-11, Vol.92 (11), p.2593-2599</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4711-9108f01360bfb5eb6f24f9b66d763e4248b8ae412bc227e4c71eb0c5dfdd2e773</citedby><cites>FETCH-LOGICAL-c4711-9108f01360bfb5eb6f24f9b66d763e4248b8ae412bc227e4c71eb0c5dfdd2e773</cites><orcidid>0000-0002-8660-9356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.26071$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.26071$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32470167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Chang‐Zheng</creatorcontrib><creatorcontrib>Hu, Shun‐Lin</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Li, Min</creatorcontrib><creatorcontrib>Li, Huan‐Tian</creatorcontrib><title>Early risk factors of the exacerbation of coronavirus disease 2019 pneumonia</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>The purpose of this study was to investigate the early risk factors for the exacerbation of coronavirus disease 2019 (COVID‐19) pneumonia. Restrospective analysis of clinical data of 85 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), including gender, age, comorbidities, symptoms, blood routine, clotting profile, biochemical examination, albumin, myocardial enzyme profile, inflammatory markers, and chest computed tomography (CT). All laboratory examinations were measured within first 24 hours after admission, and chest CT was performed before admission. A total of 56 (65.9%) patients had a history of exposure to the Huanan seafood market in Wuhan. Fever and dry cough accounted for the highest percentage of all symptoms. Male COVID‐2019 patients were more likely to develop severe pneumonia. Patients with severe and critical conditions are older and have higher rates of hypertension (P = .003) and coronary heart disease (P = .017). All severe and critical patients infected with SARS‐CoV‐2 showed bilateral lung involvement and have more multiple lobes involvement than common patients (P < .001). Severe and critical patients showed higher white blood cell count (P = .006), neutrophil (NEU) count (P = .001), NEU% (P = .002), procalcitonin (P = .011), C‐reactive protein (P = .003), prothrombin time (P = .035), D‐dimer (P = .025), aspartate aminotransferase (P = .006), and lower lymphocyte (LYM) count (P = .019), LYM% (P = .001), albumin (P < .001). Logistic regression analysis showed that NEU count is an independent risk factor for deterioration, with the threshold of 6.5 × 109·L−1. We concluded that the laboratory independent risk factor for the progression of COVID‐19 pneumonia is NEU count. In addition, COVID‐19 patients with bilateral lung involvement or multiple lobes involvement should be taken seriously and actively treated to prevent deterioration of the disease.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albumin</subject><subject>Albumins</subject><subject>Aspartate aminotransferase</subject><subject>Blood</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Chest</subject><subject>chest CT</subject><subject>China</subject><subject>clinical features</subject><subject>Clotting</subject><subject>Comorbidity</subject><subject>Computed tomography</subject><subject>Coronary artery disease</subject><subject>Coronaviridae</subject><subject>Coronaviruses</subject><subject>Cough</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - physiopathology</subject><subject>Dimers</subject><subject>Disease Progression</subject><subject>ErbB-2 protein</subject><subject>Female</subject><subject>Fever</subject><subject>Heart diseases</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Laboratories</subject><subject>Leukocytes</subject><subject>Lobes</subject><subject>Lung - pathology</subject><subject>Lung - virology</subject><subject>Lungs</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pneumonia</subject><subject>Procalcitonin</subject><subject>Prothrombin</subject><subject>Regression analysis</subject><subject>Respiratory diseases</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>SARS‐CoV‐2</subject><subject>Seafood</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Sex Factors</subject><subject>Signs and symptoms</subject><subject>Symptom Flare Up</subject><subject>Tomography, X-Ray Computed</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi0EosvCgRdAkbjAIe3Ycez4goSqlrZaxAW4WrYzpl6SeLGTbfftm2XbCpA4zWjm06cZ_YS8pnBMAdjJut8eMwGSPiELCkqUau6fkgVQLkohaH1EXuS8BoBGMfacHFWMS6BCLsjqzKRuV6SQfxbeuDGmXERfjNdY4K1xmKwZQxz2MxdTHMw2pCkXbchoMhYMqCo2A059HIJ5SZ5502V8dV-X5Nv52dfTi3L15dPl6cdV6biktFQUGg-0EmC9rdEKz7hXVohWigo5441tDHLKrGNMIneSogVXt75tGUpZLcmHg3cz2R5bh8OYTKc3KfQm7XQ0Qf-9GcK1_hG3WrKmkkzNgnf3ghR_TZhH3YfssOvMgHHKmnFoqFJVvUff_oOu45SG-b2Z4kI1op5fWZL3B8qlmHNC_3gMBb3PSM8Z6d8ZzeybP69_JB9CmYGTA3ATOtz936SvPn8_KO8A-9-baQ</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Wang, Chang‐Zheng</creator><creator>Hu, Shun‐Lin</creator><creator>Wang, Lin</creator><creator>Li, Min</creator><creator>Li, Huan‐Tian</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8660-9356</orcidid></search><sort><creationdate>202011</creationdate><title>Early risk factors of the exacerbation of coronavirus disease 2019 pneumonia</title><author>Wang, Chang‐Zheng ; Hu, Shun‐Lin ; Wang, Lin ; Li, Min ; Li, Huan‐Tian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4711-9108f01360bfb5eb6f24f9b66d763e4248b8ae412bc227e4c71eb0c5dfdd2e773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albumin</topic><topic>Albumins</topic><topic>Aspartate aminotransferase</topic><topic>Blood</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Chest</topic><topic>chest CT</topic><topic>China</topic><topic>clinical features</topic><topic>Clotting</topic><topic>Comorbidity</topic><topic>Computed tomography</topic><topic>Coronary artery disease</topic><topic>Coronaviridae</topic><topic>Coronaviruses</topic><topic>Cough</topic><topic>COVID-19</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - physiopathology</topic><topic>Dimers</topic><topic>Disease Progression</topic><topic>ErbB-2 protein</topic><topic>Female</topic><topic>Fever</topic><topic>Heart diseases</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>Laboratories</topic><topic>Leukocytes</topic><topic>Lobes</topic><topic>Lung - pathology</topic><topic>Lung - virology</topic><topic>Lungs</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pneumonia</topic><topic>Procalcitonin</topic><topic>Prothrombin</topic><topic>Regression analysis</topic><topic>Respiratory diseases</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>SARS‐CoV‐2</topic><topic>Seafood</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Sex Factors</topic><topic>Signs and symptoms</topic><topic>Symptom Flare Up</topic><topic>Tomography, X-Ray Computed</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Chang‐Zheng</creatorcontrib><creatorcontrib>Hu, Shun‐Lin</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Li, Min</creatorcontrib><creatorcontrib>Li, Huan‐Tian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Chang‐Zheng</au><au>Hu, Shun‐Lin</au><au>Wang, Lin</au><au>Li, Min</au><au>Li, Huan‐Tian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early risk factors of the exacerbation of coronavirus disease 2019 pneumonia</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2020-11</date><risdate>2020</risdate><volume>92</volume><issue>11</issue><spage>2593</spage><epage>2599</epage><pages>2593-2599</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>The purpose of this study was to investigate the early risk factors for the exacerbation of coronavirus disease 2019 (COVID‐19) pneumonia. Restrospective analysis of clinical data of 85 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), including gender, age, comorbidities, symptoms, blood routine, clotting profile, biochemical examination, albumin, myocardial enzyme profile, inflammatory markers, and chest computed tomography (CT). All laboratory examinations were measured within first 24 hours after admission, and chest CT was performed before admission. A total of 56 (65.9%) patients had a history of exposure to the Huanan seafood market in Wuhan. Fever and dry cough accounted for the highest percentage of all symptoms. Male COVID‐2019 patients were more likely to develop severe pneumonia. Patients with severe and critical conditions are older and have higher rates of hypertension (P = .003) and coronary heart disease (P = .017). All severe and critical patients infected with SARS‐CoV‐2 showed bilateral lung involvement and have more multiple lobes involvement than common patients (P < .001). Severe and critical patients showed higher white blood cell count (P = .006), neutrophil (NEU) count (P = .001), NEU% (P = .002), procalcitonin (P = .011), C‐reactive protein (P = .003), prothrombin time (P = .035), D‐dimer (P = .025), aspartate aminotransferase (P = .006), and lower lymphocyte (LYM) count (P = .019), LYM% (P = .001), albumin (P < .001). Logistic regression analysis showed that NEU count is an independent risk factor for deterioration, with the threshold of 6.5 × 109·L−1. We concluded that the laboratory independent risk factor for the progression of COVID‐19 pneumonia is NEU count. In addition, COVID‐19 patients with bilateral lung involvement or multiple lobes involvement should be taken seriously and actively treated to prevent deterioration of the disease.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32470167</pmid><doi>10.1002/jmv.26071</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8660-9356</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Albumin Albumins Aspartate aminotransferase Blood Cardiovascular disease Cardiovascular diseases Chest chest CT China clinical features Clotting Comorbidity Computed tomography Coronary artery disease Coronaviridae Coronaviruses Cough COVID-19 COVID-19 - complications COVID-19 - diagnosis COVID-19 - physiopathology Dimers Disease Progression ErbB-2 protein Female Fever Heart diseases Hospitalization Humans Hypertension Inflammation Laboratories Leukocytes Lobes Lung - pathology Lung - virology Lungs Lymphocytes Male Middle Aged Pneumonia Procalcitonin Prothrombin Regression analysis Respiratory diseases Retrospective Studies Risk analysis Risk Factors SARS‐CoV‐2 Seafood Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Sex Factors Signs and symptoms Symptom Flare Up Tomography, X-Ray Computed Viral diseases Virology |
| title | Early risk factors of the exacerbation of coronavirus disease 2019 pneumonia |
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