Spreading Depolarizations and Subarachnoid Hemorrhage

Cortical spreading depolarizations (SD) are strongly associated with worse tissue injury and clinical outcomes in the setting of aneurysmal subarachnoid hemorrhage (SAH). Animal studies have suggested a causal relationship, and new therapies to target SDs are starting to be tested in clinical studie...

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Veröffentlicht in:	Neurotherapeutics 2020-04, Vol.17 (2), p.497-510
Hauptverfasser:	Sugimoto, Kazutaka, Chung, David Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysm Animals Biomedical and Life Sciences Biomedicine Blood flow Brain injury Cerebral blood flow Clinical trials Cortical Spreading Depression - physiology Glutamic acid receptors (ionotropic) Humans Ketamine N-Methyl-D-aspartic acid receptors Neurobiology Neurology Neurosciences Neurosurgery Phosphodiesterase Phosphodiesterase inhibitors Review Spreading depression Subarachnoid hemorrhage Subarachnoid Hemorrhage - physiopathology Therapeutic applications
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