Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway

Background Stearoyl-CoA desaturase-1 (SCD1) is reported to play essential roles in cancer stemness among several cancers. Our previous research revealed significant overexpression of SCD1 in primary gastric cancer stem cells (GCSCs), with its functional role still unknown. Methods We stably establis...

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Veröffentlicht in:	British journal of cancer 2020-06, Vol.122 (12), p.1837-1847
Hauptverfasser:	Gao, Yunhe, Li, Jiyang, Xi, Hongqing, Cui, Jianxin, Zhang, Kecheng, Zhang, Jiabing, Zhang, Yanmei, Xu, Wei, Liang, Wenquan, Zhuang, Ziwei, Wang, Pengpeng, Qiao, Zhi, Wei, Bo, Chen, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1504/1829 631/67/71 Adaptor Proteins, Signal Transducing - metabolism Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Research Chemoresistance Chemotherapy Desaturase Drug Resistance Epidemiology Flow cytometry Gastric cancer Heterografts Humans Male Mesenchyme Metastases Metastasis Mice Mice, SCID Molecular Medicine Neoplasm Invasiveness - pathology Neoplasm Metastasis Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncology Protein-Serine-Threonine Kinases - metabolism Proteins Signal Transduction - physiology siRNA Stearoyl-CoA desaturase Stearoyl-CoA Desaturase - metabolism Stem cells Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Transcription Factors - metabolism Tumor Cells, Cultured Tumors Yes-associated protein
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