Changes in Nutrition Impact Symptoms, Nutritional and Functional Status during Head and Neck Cancer Treatment
The purpose of this study is to evaluate changes in nutrition impact symptoms (NIS) and nutritional and functional status that occur throughout radiotherapy in head and neck cancer (HNC) patients. A prospective observational study of HNC inpatients who underwent radiotherapy with or without chemothe...
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| Veröffentlicht in: | Nutrients 2020-04, Vol.12 (5), p.1225 |
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| creator | Neoh, May Kay Abu Zaid, Zalina Mat Daud, Zulfitri Azuan Md Yusop, Nor Baizura Ibrahim, Zuriati Abdul Rahman, Zuwariah Jamhuri, Norshariza |
| description | The purpose of this study is to evaluate changes in nutrition impact symptoms (NIS) and nutritional and functional status that occur throughout radiotherapy in head and neck cancer (HNC) patients.
A prospective observational study of HNC inpatients who underwent radiotherapy with or without chemotherapy were recruited to participate. Fifty patients were followed for the periods before, in the middle and at the end of radiotherapy. Nutritional parameters were collected throughout radiotherapy.
According to Patient-Generated Subjective Global Assessment (PG-SGA), there was an increase from a baseline of 56% malnourished HNC patients to 100% malnourished with mean weight loss of 4.53 ± 0.41kg (7.39%) at the end of radiotherapy. Nutritional parameters such as muscle mass, fat mass, body mass index, dietary energy and protein intake decrease significantly (
< 0.0001) while NIS score, energy and protein intake from oral nutritional supplements (ONS) increased significantly (
< 0.0001). Hand grip strength did not differ significantly. All HNC patients experienced taste changes and dry mouth that required ONS at the end of treatment. ONS compliance affected the percentage of weight loss (
= 0.013).
The intensive nutritional care time point was the middle of RT. The PG-SGA and NIS checklist are useful for monitoring nutrition for HNC patients. |
| doi_str_mv | 10.3390/nu12051225 |
| format | Article |
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A prospective observational study of HNC inpatients who underwent radiotherapy with or without chemotherapy were recruited to participate. Fifty patients were followed for the periods before, in the middle and at the end of radiotherapy. Nutritional parameters were collected throughout radiotherapy.
According to Patient-Generated Subjective Global Assessment (PG-SGA), there was an increase from a baseline of 56% malnourished HNC patients to 100% malnourished with mean weight loss of 4.53 ± 0.41kg (7.39%) at the end of radiotherapy. Nutritional parameters such as muscle mass, fat mass, body mass index, dietary energy and protein intake decrease significantly (
< 0.0001) while NIS score, energy and protein intake from oral nutritional supplements (ONS) increased significantly (
< 0.0001). Hand grip strength did not differ significantly. All HNC patients experienced taste changes and dry mouth that required ONS at the end of treatment. ONS compliance affected the percentage of weight loss (
= 0.013).
The intensive nutritional care time point was the middle of RT. The PG-SGA and NIS checklist are useful for monitoring nutrition for HNC patients.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12051225</identifier><identifier>PMID: 32357529</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Aged ; Body composition ; Body fat ; Body mass ; Body Mass Index ; Body size ; Body weight loss ; Cancer therapies ; Chemotherapy ; Diet ; Dietary intake ; Dietary Supplements ; Eating ; Energy ; Energy Intake ; Female ; Food ; Grip strength ; Head & neck cancer ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - physiopathology ; Head and Neck Neoplasms - radiotherapy ; Humans ; Male ; Malnutrition ; Medical prognosis ; Middle Aged ; Muscles ; Nutrition ; Nutrition Assessment ; Nutrition research ; Nutrition Therapy ; Nutritional Physiological Phenomena - physiology ; Nutritional Status ; Parenteral nutrition ; Prospective Studies ; Proteins ; Radiation therapy ; Software ; Weight Loss ; Young Adult</subject><ispartof>Nutrients, 2020-04, Vol.12 (5), p.1225</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-d8faf547a067cc415079bd9fdb5b6817174f80c988848c20b7d2a3d8fcde33163</citedby><cites>FETCH-LOGICAL-c406t-d8faf547a067cc415079bd9fdb5b6817174f80c988848c20b7d2a3d8fcde33163</cites><orcidid>0000-0002-4017-107X ; 0000-0002-9144-9190 ; 0000-0001-6210-0443</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282002/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282002/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32357529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neoh, May Kay</creatorcontrib><creatorcontrib>Abu Zaid, Zalina</creatorcontrib><creatorcontrib>Mat Daud, Zulfitri Azuan</creatorcontrib><creatorcontrib>Md Yusop, Nor Baizura</creatorcontrib><creatorcontrib>Ibrahim, Zuriati</creatorcontrib><creatorcontrib>Abdul Rahman, Zuwariah</creatorcontrib><creatorcontrib>Jamhuri, Norshariza</creatorcontrib><title>Changes in Nutrition Impact Symptoms, Nutritional and Functional Status during Head and Neck Cancer Treatment</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The purpose of this study is to evaluate changes in nutrition impact symptoms (NIS) and nutritional and functional status that occur throughout radiotherapy in head and neck cancer (HNC) patients.
A prospective observational study of HNC inpatients who underwent radiotherapy with or without chemotherapy were recruited to participate. Fifty patients were followed for the periods before, in the middle and at the end of radiotherapy. Nutritional parameters were collected throughout radiotherapy.
According to Patient-Generated Subjective Global Assessment (PG-SGA), there was an increase from a baseline of 56% malnourished HNC patients to 100% malnourished with mean weight loss of 4.53 ± 0.41kg (7.39%) at the end of radiotherapy. Nutritional parameters such as muscle mass, fat mass, body mass index, dietary energy and protein intake decrease significantly (
< 0.0001) while NIS score, energy and protein intake from oral nutritional supplements (ONS) increased significantly (
< 0.0001). Hand grip strength did not differ significantly. All HNC patients experienced taste changes and dry mouth that required ONS at the end of treatment. ONS compliance affected the percentage of weight loss (
= 0.013).
The intensive nutritional care time point was the middle of RT. 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A prospective observational study of HNC inpatients who underwent radiotherapy with or without chemotherapy were recruited to participate. Fifty patients were followed for the periods before, in the middle and at the end of radiotherapy. Nutritional parameters were collected throughout radiotherapy.
According to Patient-Generated Subjective Global Assessment (PG-SGA), there was an increase from a baseline of 56% malnourished HNC patients to 100% malnourished with mean weight loss of 4.53 ± 0.41kg (7.39%) at the end of radiotherapy. Nutritional parameters such as muscle mass, fat mass, body mass index, dietary energy and protein intake decrease significantly (
< 0.0001) while NIS score, energy and protein intake from oral nutritional supplements (ONS) increased significantly (
< 0.0001). Hand grip strength did not differ significantly. All HNC patients experienced taste changes and dry mouth that required ONS at the end of treatment. ONS compliance affected the percentage of weight loss (
= 0.013).
The intensive nutritional care time point was the middle of RT. The PG-SGA and NIS checklist are useful for monitoring nutrition for HNC patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32357529</pmid><doi>10.3390/nu12051225</doi><orcidid>https://orcid.org/0000-0002-4017-107X</orcidid><orcidid>https://orcid.org/0000-0002-9144-9190</orcidid><orcidid>https://orcid.org/0000-0001-6210-0443</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Aged Body composition Body fat Body mass Body Mass Index Body size Body weight loss Cancer therapies Chemotherapy Diet Dietary intake Dietary Supplements Eating Energy Energy Intake Female Food Grip strength Head & neck cancer Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - physiopathology Head and Neck Neoplasms - radiotherapy Humans Male Malnutrition Medical prognosis Middle Aged Muscles Nutrition Nutrition Assessment Nutrition research Nutrition Therapy Nutritional Physiological Phenomena - physiology Nutritional Status Parenteral nutrition Prospective Studies Proteins Radiation therapy Software Weight Loss Young Adult |
| title | Changes in Nutrition Impact Symptoms, Nutritional and Functional Status during Head and Neck Cancer Treatment |
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