Role of Calcium Signaling in Prostate Cancer Progression: Effects on Cancer Hallmarks and Bone Metastatic Mechanisms

Advanced prostate cancers that progress to tumor metastases are often considered incurable or difficult to treat. The etiology of prostate cancers is multi-factorial. Among other factors, de-regulation of calcium signals in prostate tumor cells mediates several pathological dysfunctions associated w...

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Veröffentlicht in:	Cancers 2020-04, Vol.12 (5), p.1071
Hauptverfasser:	Ardura, Juan A, Álvarez-Carrión, Luis, Gutiérrez-Rojas, Irene, Alonso, Verónica
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Apoptosis Bone cancer Ca2+-transporting ATPase Calcium (intracellular) Calcium channels Calcium channels (voltage-gated) Calcium signalling Cancer therapies Cell adhesion & migration Cell death Cell growth Endoplasmic reticulum Etiology Gene expression Homeostasis Localization Medical prognosis Metastases Metastasis Mitochondria Mortality Prostate cancer Proteins Review Signal transduction Transient receptor potential proteins Tropism Tumor cells Tumors
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