Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity

Anti-CD40 monoclonal antibodies (mAbs) comprise agonists and antagonists, which display promising therapeutic activities in cancer and autoimmunity, respectively. We previously showed that epitope and isotype interact to deliver optimal agonistic anti-CD40 mAbs. The impact of Fc engineering on antag...

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Veröffentlicht in:	Cancer cell 2020-06, Vol.37 (6), p.850-866.e7
Hauptverfasser:	Yu, Xiaojie, Chan, H.T. Claude, Fisher, Hayden, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., English, Vikki, Verbeek, J. Sjef, White, Ann L., Tews, Ivo, Glennie, Martin J., Cragg, Mark S.
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Animals antagonists Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology antibody CD40 CD40 Antigens - immunology CD40 Ligand - immunology Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Dendritic Cells - drug effects Dendritic Cells - immunology Fc engineering hIgG2 Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - immunology Immunoglobulin G - immunology immunostimulatory immunotherapy Lung Neoplasms - drug therapy Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mice, Inbred C57BL Mice, Knockout Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Receptors, IgE - physiology Receptors, IgG - physiology structure function Thymus Neoplasms - drug therapy Thymus Neoplasms - immunology Thymus Neoplasms - metabolism Thymus Neoplasms - pathology TNF receptor
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