Histone deacetylase inhibitor CG200745 ameliorates high-fat diet-induced hypertension via inhibition of angiotensin II production

Obesity is growing rapidly worldwide due to consumption of westernized diet and lack of exercise. Obesity is one of the major risk factors of hypertension. The novel histone deacetylase (HDAC) inhibitor CG200745 was originally developed to treat various cancers. Previous studies showed that CG200745...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2020-03, Vol.393 (3), p.491-500
Hauptverfasser:	Yoon, Ga-Eun, Jung, Jin Ki, Lee, Yun-Han, Jang, Byeong-Churl, In Kim, Jee
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Angiotensin Angiotensin II Angiotensin II - blood Angiotensinogen Animals Biomedical and Life Sciences Biomedicine Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Body weight Contraction Diet, High-Fat - adverse effects Fibrosis High fat diet Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Hypertension Hypertension - blood Hypertension - drug therapy Hypertension - etiology Hypertrophy Kidneys Male Mice Mice, Inbred C57BL Myosin Naphthalenes - pharmacology Naphthalenes - therapeutic use Neurosciences Obesity Original Original Article Peptidyl-dipeptidase A Pharmacology/Toxicology Phosphorylation Renin Risk factors
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