A variant of human growth differentiation factor-9 that improves oocyte developmental competence

Growth differentiation factor-9 (GDF9) and bone morphogenetic protein-15 (BMP15) are co-expressed exclusively in oocytes throughout most of folliculogenesis and play central roles in controlling ovarian physiology. Although both growth factors exist as homodimers, recent evidence indicates that GDF9...

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Veröffentlicht in:	The Journal of biological chemistry 2020-06, Vol.295 (23), p.7981-7991
Hauptverfasser:	Stocker, William A., Walton, Kelly L., Richani, Dulama, Chan, Karen L., Beilby, Kiri H., Finger, Bethany J., Green, Mark P., Gilchrist, Robert B., Harrison, Craig A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry & Molecular Biology BMP15 bone morphogenetic protein (BMP) Bone Morphogenetic Protein 15 - genetics Bone Morphogenetic Protein 15 - metabolism Cell Line, Tumor cumulin Female GDF9 Genetic Variation - genetics granulosa cells Growth Differentiation Factor 9 - genetics Growth Differentiation Factor 9 - metabolism growth factor Humans Life Sciences & Biomedicine Mice Models, Molecular oocyte maturation Oocytes - metabolism ovary Protein Structure and Folding receptor protein serine/threonine kinase Science & Technology Signal Transduction SMAD transcription factor Smad2 Protein - metabolism Smad3 Protein - metabolism
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