Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject 21 da...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2020-07, Vol.53 (1), p.98-105.e5
Hauptverfasser:	Seydoux, Emilie, Homad, Leah J., MacCamy, Anna J., Parks, K. Rachael, Hurlburt, Nicholas K., Jennewein, Madeleine F., Akins, Nicholas R., Stuart, Andrew B., Wan, Yu-Hsin, Feng, Junli, Whaley, Rachael E., Singh, Suruchi, Boeckh, Michael, Cohen, Kristen W., McElrath, M. Juliana, Englund, Janet A., Chu, Helen Y., Pancera, Marie, McGuire, Andrew T., Stamatatos, Leonidas
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin-Converting Enzyme 2 Antibodies Antibodies, Monoclonal - immunology Antibodies, Neutralizing - immunology Antibodies, Viral - immunology B cells B-Lymphocytes - immunology Betacoronavirus - immunology Binding Binding Sites Coronavirus Infections - immunology Coronavirus Infections - prevention & control Coronaviruses COVID-19 Epitopes Epitopes, B-Lymphocyte - immunology Glycoproteins Humans Infections Lymphocytes B MERS Monoclonal antibodies Mutation neutralization Neutralizing Pandemics Pandemics - prevention & control Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - immunology Pneumonia, Viral - prevention & control Protein Binding Proteins receptor-binding domain Receptors Receptors, Virus - metabolism SARS SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Somatic Hypermutation, Immunoglobulin - genetics Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism spike protein Vaccines Viral diseases Viral Vaccines - immunology Viruses
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