Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization

Free-living mammals, such as humans and wild mice, display heightened immune activation compared with artificially maintained laboratory mice. These differences are partially attributed to microbial exposure as laboratory mice infected with pathogens exhibit immune profiles more closely resembling t...

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Veröffentlicht in:	Cell host & microbe 2020-05, Vol.27 (5), p.809-822.e6
Hauptverfasser:	Yeung, Frank, Chen, Ying-Han, Lin, Jian-Da, Leung, Jacqueline M., McCauley, Caroline, Devlin, Joseph C., Hansen, Christina, Cronkite, Alex, Stephens, Zac, Drake-Dunn, Charlotte, Fulmer, Yi, Shopsin, Bo, Ruggles, Kelly V., Round, June L., Loke, P’ng, Graham, Andrea L., Cadwell, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspergillus Autophagy-Related Proteins - genetics CD8-Positive T-Lymphocytes Environment Feces - microbiology Female fungi Fungi - genetics Fungi - growth & development Fungi - isolation & purification Fungi - physiology Gastrointestinal Microbiome - immunology granulocytes Granulocytes - immunology Immune System Intestines - microbiology Intestines - pathology laboratory mice Lymphocytes Male mesocosm Mice Mice, Inbred C57BL Mice, Knockout microbiota Mycobiome - immunology Mycobiome - physiology mycobiota neutrophils Nod2 Signaling Adaptor Protein - genetics rewilding wild mice
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