Zinc Oxide Nanoparticle Synergizes Sorafenib Anticancer Efficacy with Minimizing Its Cytotoxicity

Cancer, as a group, represents the most important cause of death worldwide. Unfortunately, the available therapeutic approaches of cancer including surgery, chemotherapy, radiotherapy, and immunotherapy are unsatisfactory and represent a great challenge as many patients have cancer recurrence and se...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-11
Hauptverfasser:	Ebara, Mitsuhiro, Zahran, Fatin, Gomaa, Heba F., Abdel-Motaal, Marwa, Asem, Medhat, Elshemy, Mohamed M., Nabil Ahmed, Ahmed, Uto, Koichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Binding sites Cancer Cancer therapies Caspase 3 - metabolism Cell growth Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy Cytochrome Cytochrome c Cytochromes c - metabolism Cytotoxicity Deoxyribonucleic acid Dihydrofolate reductase DNA DNA - metabolism DNA Fragmentation - drug effects Drug dosages Enzymes Female Flow cytometry Health aspects Immunosuppressive agents Inhibitor drugs Kinases Laboratory animals Liver cancer Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Mice Oxidative Stress - drug effects Pemetrexed Reactive oxygen species Sorafenib - pharmacology Targeted cancer therapy Tumor Burden - drug effects Tumors Zinc oxide Zinc Oxide - pharmacology Zinc oxides
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