A comparison of microfluidic methods for high-throughput cell deformability measurements

The mechanical phenotype of a cell is an inherent biophysical marker of its state and function, with many applications in basic and applied biological research. Microfluidics-based methods have enabled single-cell mechanophenotyping at throughputs comparable to those of flow cytometry. Here, we pres...

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Veröffentlicht in:	Nature methods 2020-06, Vol.17 (6), p.587-593
Hauptverfasser:	Urbanska, Marta, Muñoz, Hector E., Shaw Bagnall, Josephine, Otto, Oliver, Manalis, Scott R., Di Carlo, Dino, Guck, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2204 631/1647/277 Actin Actins - drug effects Analysis Bioengineering Bioinformatics Biological Microscopy Biological research Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Cancer Cell cycle Cell Shape - drug effects Cell Size - drug effects Change detection Comparative analysis Cytoskeleton Cytoskeleton - drug effects Deformability Deformation Dose-Response Relationship, Drug Flow cytometry Flow Cytometry - methods Flow velocity Formability Genotype & phenotype HL-60 Cells Humans Image Processing, Computer-Assisted Latrunculin B Life Sciences Mechanical properties Mechanics Medical laboratories Medical research Methods Microfluidics Microfluidics - methods Muscle proteins Osmolarity Phenotypes Proteomics Reynolds number Shear flow Strain rate Thiazolidines - administration & dosage Viscosity
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