Directed evolution of Anabaena variabilis phenylalanine ammonia-lyase (PAL) identifies mutants with enhanced activities

There is broad interest in engineering phenylalanine ammonia-lyase (PAL) for its biocatalytic applications in industry and medicine. While site-specific mutagenesis has been employed to improve PAL stability or substrate specificity, combinatorial techniques are poorly explored. Here, we report deve...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-05, Vol.56 (39), p.5255-5258
Hauptverfasser: Mays, Zachary Js, Mohan, Karishma, Trivedi, Vikas D, Chappell, Todd C, Nair, Nikhil U
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Sprache:eng
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