Inhalation delivery technology for genome-editing of respiratory diseases

The clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) system has significant therapeutic potentials for lung congenital diseases such as cystic fibrosis, as well as other pulmonary disorders like lung cancer and obstructive diseases. Local...

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Veröffentlicht in:	Advanced drug delivery reviews 2021-01, Vol.168, p.217-228
Hauptverfasser:	Chow, Michael Y.T., Chang, Rachel Yoon Kyung, Chan, Hak-Kim
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosol formulation CRISPR Dry powder inhaler Gene therapy mRNA Nebulisation Plasmids Ribonucleoprotein
Online-Zugang:	Volltext
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